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Antiplatelet Activity, P2Y(1) and P2Y(12) Inhibition, and Metabolism in Plasma of Stereoisomers of Diadenosine 5′,5′″-P(1),P(4)-dithio-P(2),P(3)-chloromethylenetetraphosphate

BACKGROUND: Diadenosine tetraphosphate (Ap(4)A), a constituent of platelet dense granules, and its P(1),P(4)-dithio and/or P(2),P(3)-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation. We recently reported that these compounds antagonize both platelet ADP recep...

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Detalles Bibliográficos
Autores principales:	Chang, Hung, Yanachkov, Ivan B., Dix, Edward J., Yanachkova, Milka, Li, YouFu, Barnard, Marc R., Wright, George E., Michelson, Alan D., Frelinger, Andrew L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983250/ https://www.ncbi.nlm.nih.gov/pubmed/24722456 http://dx.doi.org/10.1371/journal.pone.0094780

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