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Functionally Distinct Effects of the C-Terminal Regions of IKKε and TBK1 on Type I IFN Production
Inhibitor of κB kinase ε (IKKε) and TANK binding kinase 1 (TBK1), so-called non-canonical IKKs or IKK-related kinases, are involved in the cellular innate immunity by inducing type I IFNs. Two kinases commonly phosphorylate transcription factors IRF3 and IRF7 in type I IFN production pathway. In con...
Autores principales: | Nakatsu, Yuichiro, Matsuoka, Mayumi, Chang, Tsung-Hsien, Otsuki, Noriyuki, Noda, Masahiro, Kimura, Hirokazu, Sakai, Kouji, Kato, Hiroshi, Takeda, Makoto, Kubota, Toru |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983252/ https://www.ncbi.nlm.nih.gov/pubmed/24722368 http://dx.doi.org/10.1371/journal.pone.0094999 |
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