Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides

[Image: see text] An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. The transformation is facilitated by the use of our newly developed Pd precatalyst based on the bulky biarylphosphine ligand tBuBrettPhos (L4). The mild reactio...

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Detalles Bibliográficos
Autores principales: Su, Mingjuan, Hoshiya, Naoyuki, Buchwald, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983327/
https://www.ncbi.nlm.nih.gov/pubmed/24417224
http://dx.doi.org/10.1021/ol4035947
Descripción
Sumario:[Image: see text] An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. The transformation is facilitated by the use of our newly developed Pd precatalyst based on the bulky biarylphosphine ligand tBuBrettPhos (L4). The mild reaction conditions employed allow for the preparation of a broad scope of aminoimidazoles and aminopyrazoles in moderate to excellent yields.

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