Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides

[Image: see text] An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. The transformation is facilitated by the use of our newly developed Pd precatalyst based on the bulky biarylphosphine ligand tBuBrettPhos (L4). The mild reactio...

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Autores principales: Su, Mingjuan, Hoshiya, Naoyuki, Buchwald, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983327/
https://www.ncbi.nlm.nih.gov/pubmed/24417224
http://dx.doi.org/10.1021/ol4035947
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author Su, Mingjuan
Hoshiya, Naoyuki
Buchwald, Stephen L.
author_facet Su, Mingjuan
Hoshiya, Naoyuki
Buchwald, Stephen L.
author_sort Su, Mingjuan
collection PubMed
description [Image: see text] An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. The transformation is facilitated by the use of our newly developed Pd precatalyst based on the bulky biarylphosphine ligand tBuBrettPhos (L4). The mild reaction conditions employed allow for the preparation of a broad scope of aminoimidazoles and aminopyrazoles in moderate to excellent yields.
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spelling pubmed-39833272015-01-13 Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides Su, Mingjuan Hoshiya, Naoyuki Buchwald, Stephen L. Org Lett [Image: see text] An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. The transformation is facilitated by the use of our newly developed Pd precatalyst based on the bulky biarylphosphine ligand tBuBrettPhos (L4). The mild reaction conditions employed allow for the preparation of a broad scope of aminoimidazoles and aminopyrazoles in moderate to excellent yields. American Chemical Society 2014-01-13 2014-02-07 /pmc/articles/PMC3983327/ /pubmed/24417224 http://dx.doi.org/10.1021/ol4035947 Text en Copyright © 2014 American Chemical Society
spellingShingle Su, Mingjuan
Hoshiya, Naoyuki
Buchwald, Stephen L.
Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides
title Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides
title_full Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides
title_fullStr Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides
title_full_unstemmed Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides
title_short Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides
title_sort palladium-catalyzed amination of unprotected five-membered heterocyclic bromides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983327/
https://www.ncbi.nlm.nih.gov/pubmed/24417224
http://dx.doi.org/10.1021/ol4035947
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AT hoshiyanaoyuki palladiumcatalyzedaminationofunprotectedfivememberedheterocyclicbromides
AT buchwaldstephenl palladiumcatalyzedaminationofunprotectedfivememberedheterocyclicbromides

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