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Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering

[Image: see text] In the ongoing search for ever-brighter surface-enhanced Raman scattering (SERS) nanoprobes, gold nanostars (AuNSs) have emerged as one of the best geometries for producing SERS in a nonaggregated state. Despite their high enhancement factor, optical extinction from plasmon-matched...

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Autores principales: Fales, Andrew M., Yuan, Hsiangkuo, Vo-Dinh, Tuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983328/
https://www.ncbi.nlm.nih.gov/pubmed/24803974
http://dx.doi.org/10.1021/jp4091393
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author Fales, Andrew M.
Yuan, Hsiangkuo
Vo-Dinh, Tuan
author_facet Fales, Andrew M.
Yuan, Hsiangkuo
Vo-Dinh, Tuan
author_sort Fales, Andrew M.
collection PubMed
description [Image: see text] In the ongoing search for ever-brighter surface-enhanced Raman scattering (SERS) nanoprobes, gold nanostars (AuNSs) have emerged as one of the best geometries for producing SERS in a nonaggregated state. Despite their high enhancement factor, optical extinction from plasmon-matched nanoparticles can greatly attenuate the overall SERS intensity. Herein, we report the development of a new hybrid bimetallic NS-based platform that exhibits superior resonant SERS (SERRS) properties. In this new nanoplatform, coating AuNSs with a subtotal layer of silver (AuNS@Ag) can further increase their SERRS brightness by an order of magnitude when being interrogated by an off-resonant excitation source. Silica-encapsulated AuNS@Ag nanoprobes were injected intradermally into a rat pelt, where SERRS was readily detected with higher signal-to-noise than nanoprobes prepared from AuNS. Moreover, these off-resonance AuNS@Ag nanoprobes did not cause any gross photothermal damage to tissue, which was observed with the plasmon-matched AuNSs. This novel SERRS-active hybrid nanoprobe exhibits high SERRS brightness and offers promising properties for future applications in sensing and molecular imaging.
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spelling pubmed-39833282014-05-07 Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering Fales, Andrew M. Yuan, Hsiangkuo Vo-Dinh, Tuan J Phys Chem C Nanomater Interfaces [Image: see text] In the ongoing search for ever-brighter surface-enhanced Raman scattering (SERS) nanoprobes, gold nanostars (AuNSs) have emerged as one of the best geometries for producing SERS in a nonaggregated state. Despite their high enhancement factor, optical extinction from plasmon-matched nanoparticles can greatly attenuate the overall SERS intensity. Herein, we report the development of a new hybrid bimetallic NS-based platform that exhibits superior resonant SERS (SERRS) properties. In this new nanoplatform, coating AuNSs with a subtotal layer of silver (AuNS@Ag) can further increase their SERRS brightness by an order of magnitude when being interrogated by an off-resonant excitation source. Silica-encapsulated AuNS@Ag nanoprobes were injected intradermally into a rat pelt, where SERRS was readily detected with higher signal-to-noise than nanoprobes prepared from AuNS. Moreover, these off-resonance AuNS@Ag nanoprobes did not cause any gross photothermal damage to tissue, which was observed with the plasmon-matched AuNSs. This novel SERRS-active hybrid nanoprobe exhibits high SERRS brightness and offers promising properties for future applications in sensing and molecular imaging. American Chemical Society 2014-01-14 2014-02-20 /pmc/articles/PMC3983328/ /pubmed/24803974 http://dx.doi.org/10.1021/jp4091393 Text en Copyright © 2014 American Chemical Society
spellingShingle Fales, Andrew M.
Yuan, Hsiangkuo
Vo-Dinh, Tuan
Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering
title Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering
title_full Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering
title_fullStr Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering
title_full_unstemmed Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering
title_short Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering
title_sort development of hybrid silver-coated gold nanostars for nonaggregated surface-enhanced raman scattering
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983328/
https://www.ncbi.nlm.nih.gov/pubmed/24803974
http://dx.doi.org/10.1021/jp4091393
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