Silicate Esters of Paclitaxel and Docetaxel: Synthesis, Hydrophobicity, Hydrolytic Stability, Cytotoxicity, and Prodrug Potential

[Image: see text] We report here the synthesis and selected properties of various silicate ester derivatives (tetraalkoxysilanes) of the taxanes paclitaxel (PTX) and docetaxel (DTX) [i.e., PTX-OSi(OR)(3) and DTX-OSi(OR)(3)]. Both the hydrophobicity and hydrolytic lability of these silicates can be (...

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Detalles Bibliográficos
Autores principales: Wohl, Adam R., Michel, Andrew R., Kalscheuer, Stephen, Macosko, Christopher W., Panyam, Jayanth, Hoye, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983351/
https://www.ncbi.nlm.nih.gov/pubmed/24564494
http://dx.doi.org/10.1021/jm401708f

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