Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma

[Image: see text] Selective inhibitors of neuronal nitric oxide synthase (nNOS) are regarded as valuable and powerful agents with therapeutic potential for the treatment of chronic neurodegenerative pathologies and human melanoma. Here, we describe a novel hybrid strategy that combines the pharmacok...

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Detalles Bibliográficos
Autores principales: Huang, He, Li, Huiying, Yang, Sun, Chreifi, Georges, Martásek, Pavel, Roman, Linda J., Meyskens, Frank L., Poulos, Thomas L., Silverman, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983353/
https://www.ncbi.nlm.nih.gov/pubmed/24447275
http://dx.doi.org/10.1021/jm401252e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983353/
https://www.ncbi.nlm.nih.gov/pubmed/24447275
http://dx.doi.org/10.1021/jm401252e

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