The Antitumor Agent PBT-1 Directly Targets HSP90 and hnRNP A2/B1 and Inhibits Lung Adenocarcinoma Growth and Metastasis

[Image: see text] Natural products are the major sources of currently available anticancer drugs. We recently reported that phenanthrene-based tylophorine derivative-1 (PBT-1) may be a potential antitumor agent for lung adenocarcinoma. We therefore examined the direct targets of PBT-1 and their effe...

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Detalles Bibliográficos
Autores principales: Chen, Chi-Yuan, Yang, Shuenn-Chen, Lee, Kuo-Hsiung, Yang, Xiaoming, Wei, Lin-Yi, Chow, Lu-Ping, Wang, Tzu-Chien V., Hong, Tse-Ming, Lin, Jau-Chen, Kuan, Crysline, Yang, Pan-Chyr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983378/
https://www.ncbi.nlm.nih.gov/pubmed/24428777
http://dx.doi.org/10.1021/jm401686b

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