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Discovery of 8-Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)

[Image: see text] The success of imatinib, a BCR-ABL inhibitor for the treatment of chronic myelogenous leukemia, has created a great impetus for the development of additional kinase inhibitors as therapeutic agents. However, the complexity of cancer has led to recent interest in polypharmacological...

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Detalles Bibliográficos
Autores principales:	Reddy, M. V. Ramana, Akula, Balireddy, Cosenza, Stephen C., Athuluridivakar, Saikrishna, Mallireddigari, Muralidhar R., Pallela, Venkat R., Billa, Vinay K., Subbaiah, D. R. C. Venkata, Bharathi, E. Vijaya, Vasquez-Del Carpio, Rodrigo, Padgaonkar, Amol, Baker, Stacey J., Reddy, E. Premkumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983396/ https://www.ncbi.nlm.nih.gov/pubmed/24417566 http://dx.doi.org/10.1021/jm401073p

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