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Reduction in labor pain by intrathecal midazolam as an adjunct to sufentanil

BACKGROUND: Anesthesia today has strived to decrease labor pain in a tolerable and controllable fashion. Intrathecal midazolam has been introduced as an adjunct to analgesics. The study was planned to assess the efficacy, safety and duration of analgesia produced by intrathecal midazolam adjunct to...

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Autores principales: Salimi, Alireza, Nejad, Reza Amin, Safari, Farhad, Mohajaerani, Seyed Amir, Naghade, Rahim Jahanbakhsh, Mottaghi, Kamran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Anesthesiologists 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983416/
https://www.ncbi.nlm.nih.gov/pubmed/24729842
http://dx.doi.org/10.4097/kjae.2014.66.3.204
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author Salimi, Alireza
Nejad, Reza Amin
Safari, Farhad
Mohajaerani, Seyed Amir
Naghade, Rahim Jahanbakhsh
Mottaghi, Kamran
author_facet Salimi, Alireza
Nejad, Reza Amin
Safari, Farhad
Mohajaerani, Seyed Amir
Naghade, Rahim Jahanbakhsh
Mottaghi, Kamran
author_sort Salimi, Alireza
collection PubMed
description BACKGROUND: Anesthesia today has strived to decrease labor pain in a tolerable and controllable fashion. Intrathecal midazolam has been introduced as an adjunct to analgesics. The study was planned to assess the efficacy, safety and duration of analgesia produced by intrathecal midazolam adjunct to sufentanil in decreasing labor pain. METHODS: In a randomized clinical trial 80 parturient included in the study. The two groups were matched for age, cervical dilation, gravid, gestational age, and other demographic characteristics. Combination of sufentanil and midazolam administered intrathecally to experimental group and compared to sufentanil group. Time to reach maximum block, and pain score was measured and recorded. RESULTS: Groups were matched for age and weight and other demographic characteristic. No significant adverse effect was seen in both groups including decrease in Apgar score. Duration of analgesia was 92.0 ± 12.7 in sufentanil group and 185.2 ± 15.2 minutes in midazolam and sufentanil group which was significantly different (P = 0.002). Numeric rating scale score was significantly lower in midazolam group compare to sufentanil group at 120 min (P = 0.01), 150 min (P = 0.0014), and 180 min (P = 0.001). CONCLUSIONS: Intrathecal midazolam as an adjunct to opioid could significantly enhance analgesia in labor pain with no significant adverse effect. Intrathecal injection of midazolam is an appropriate alternative to parenteral or epidural analgesia in small hospital settings.
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spelling pubmed-39834162014-04-11 Reduction in labor pain by intrathecal midazolam as an adjunct to sufentanil Salimi, Alireza Nejad, Reza Amin Safari, Farhad Mohajaerani, Seyed Amir Naghade, Rahim Jahanbakhsh Mottaghi, Kamran Korean J Anesthesiol Clinical Research Article BACKGROUND: Anesthesia today has strived to decrease labor pain in a tolerable and controllable fashion. Intrathecal midazolam has been introduced as an adjunct to analgesics. The study was planned to assess the efficacy, safety and duration of analgesia produced by intrathecal midazolam adjunct to sufentanil in decreasing labor pain. METHODS: In a randomized clinical trial 80 parturient included in the study. The two groups were matched for age, cervical dilation, gravid, gestational age, and other demographic characteristics. Combination of sufentanil and midazolam administered intrathecally to experimental group and compared to sufentanil group. Time to reach maximum block, and pain score was measured and recorded. RESULTS: Groups were matched for age and weight and other demographic characteristic. No significant adverse effect was seen in both groups including decrease in Apgar score. Duration of analgesia was 92.0 ± 12.7 in sufentanil group and 185.2 ± 15.2 minutes in midazolam and sufentanil group which was significantly different (P = 0.002). Numeric rating scale score was significantly lower in midazolam group compare to sufentanil group at 120 min (P = 0.01), 150 min (P = 0.0014), and 180 min (P = 0.001). CONCLUSIONS: Intrathecal midazolam as an adjunct to opioid could significantly enhance analgesia in labor pain with no significant adverse effect. Intrathecal injection of midazolam is an appropriate alternative to parenteral or epidural analgesia in small hospital settings. The Korean Society of Anesthesiologists 2014-03 2014-03-28 /pmc/articles/PMC3983416/ /pubmed/24729842 http://dx.doi.org/10.4097/kjae.2014.66.3.204 Text en Copyright © the Korean Society of Anesthesiologists, 2014 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Article
Salimi, Alireza
Nejad, Reza Amin
Safari, Farhad
Mohajaerani, Seyed Amir
Naghade, Rahim Jahanbakhsh
Mottaghi, Kamran
Reduction in labor pain by intrathecal midazolam as an adjunct to sufentanil
title Reduction in labor pain by intrathecal midazolam as an adjunct to sufentanil
title_full Reduction in labor pain by intrathecal midazolam as an adjunct to sufentanil
title_fullStr Reduction in labor pain by intrathecal midazolam as an adjunct to sufentanil
title_full_unstemmed Reduction in labor pain by intrathecal midazolam as an adjunct to sufentanil
title_short Reduction in labor pain by intrathecal midazolam as an adjunct to sufentanil
title_sort reduction in labor pain by intrathecal midazolam as an adjunct to sufentanil
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983416/
https://www.ncbi.nlm.nih.gov/pubmed/24729842
http://dx.doi.org/10.4097/kjae.2014.66.3.204
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