Non-integrating gamma-retroviral vectors as a versatile tool for transient zinc-finger nuclease delivery

Designer nucleases, like zinc-finger nucleases (ZFNs), represent valuable tools for targeted genome editing. Here, we took advantage of the gamma-retroviral life cycle and produced vectors to transfer ZFNs in the form of protein, mRNA and episomal DNA. Transfer efficacy and ZFN activity were assesse...

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Detalles Bibliográficos
Autores principales: Bobis-Wozowicz, Sylwia, Galla, Melanie, Alzubi, Jamal, Kuehle, Johannes, Baum, Christopher, Schambach, Axel, Cathomen, Toni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983605/
https://www.ncbi.nlm.nih.gov/pubmed/24722320
http://dx.doi.org/10.1038/srep04656

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