A systems framework for vaccine design

Numerous challenges have been identified in vaccine development, including variable efficacy as a function of population demographics and a lack of characterization and mechanistic understanding of immune correlates of protection able to guide delivery and dosing. There is tremendous opportunity in...

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Autores principales: Mooney, Michael, McWeeney, Shannon, Canderan, Glenda, Sékaly, Rafick-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983719/
https://www.ncbi.nlm.nih.gov/pubmed/24358511
http://dx.doi.org/10.1016/j.coi.2013.09.014
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author Mooney, Michael
McWeeney, Shannon
Canderan, Glenda
Sékaly, Rafick-Pierre
author_facet Mooney, Michael
McWeeney, Shannon
Canderan, Glenda
Sékaly, Rafick-Pierre
author_sort Mooney, Michael
collection PubMed
description Numerous challenges have been identified in vaccine development, including variable efficacy as a function of population demographics and a lack of characterization and mechanistic understanding of immune correlates of protection able to guide delivery and dosing. There is tremendous opportunity in recent technological and computational advances to elucidate systems level understanding of pathogen–host interactions and correlates of immunity. A systems biology approach to vaccinology provides a new paradigm for rational vaccine design in a ‘precision medicine’ context.
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spelling pubmed-39837192014-10-01 A systems framework for vaccine design Mooney, Michael McWeeney, Shannon Canderan, Glenda Sékaly, Rafick-Pierre Curr Opin Immunol Article Numerous challenges have been identified in vaccine development, including variable efficacy as a function of population demographics and a lack of characterization and mechanistic understanding of immune correlates of protection able to guide delivery and dosing. There is tremendous opportunity in recent technological and computational advances to elucidate systems level understanding of pathogen–host interactions and correlates of immunity. A systems biology approach to vaccinology provides a new paradigm for rational vaccine design in a ‘precision medicine’ context. Published by Elsevier Ltd. 2013-10 2013-10-23 /pmc/articles/PMC3983719/ /pubmed/24358511 http://dx.doi.org/10.1016/j.coi.2013.09.014 Text en Copyright © 2013 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mooney, Michael
McWeeney, Shannon
Canderan, Glenda
Sékaly, Rafick-Pierre
A systems framework for vaccine design
title A systems framework for vaccine design
title_full A systems framework for vaccine design
title_fullStr A systems framework for vaccine design
title_full_unstemmed A systems framework for vaccine design
title_short A systems framework for vaccine design
title_sort systems framework for vaccine design
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983719/
https://www.ncbi.nlm.nih.gov/pubmed/24358511
http://dx.doi.org/10.1016/j.coi.2013.09.014
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