Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle

We have identified integrin beta 6 (Itgb6) as a transcript highly enriched in skeletal muscle. This finding is unexpected because Itgb6 is typically associated with epithelial expression domains in normal tissue. Further we find that ITGB6 protein expression in muscle is post-transcriptionally regul...

Descripción completa

Detalles Bibliográficos
Autores principales: Ducceschi, Melissa, Clifton, Lisa G., Stimpson, Stephen A., Billin, Andrew N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983900/
https://www.ncbi.nlm.nih.gov/pubmed/24488487
http://dx.doi.org/10.1007/s10735-014-9567-2
_version_ 1782311378182209536
author Ducceschi, Melissa
Clifton, Lisa G.
Stimpson, Stephen A.
Billin, Andrew N.
author_facet Ducceschi, Melissa
Clifton, Lisa G.
Stimpson, Stephen A.
Billin, Andrew N.
author_sort Ducceschi, Melissa
collection PubMed
description We have identified integrin beta 6 (Itgb6) as a transcript highly enriched in skeletal muscle. This finding is unexpected because Itgb6 is typically associated with epithelial expression domains in normal tissue. Further we find that ITGB6 protein expression in muscle is post-transcriptionally regulated. Uninjured muscle expresses Itgb6 RNA but no ITGB6 protein is detectable. Muscle injury induces ITGB6 protein accumulation rapidly post-injury in myofibers adjacent to the site of injury. As regeneration of the injured muscle tissue progresses ITGB6 protein is found in newly formed fibers up to at least 15 days post-injury.
format Online
Article
Text
id pubmed-3983900
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-39839002014-04-16 Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle Ducceschi, Melissa Clifton, Lisa G. Stimpson, Stephen A. Billin, Andrew N. J Mol Histol Original Paper We have identified integrin beta 6 (Itgb6) as a transcript highly enriched in skeletal muscle. This finding is unexpected because Itgb6 is typically associated with epithelial expression domains in normal tissue. Further we find that ITGB6 protein expression in muscle is post-transcriptionally regulated. Uninjured muscle expresses Itgb6 RNA but no ITGB6 protein is detectable. Muscle injury induces ITGB6 protein accumulation rapidly post-injury in myofibers adjacent to the site of injury. As regeneration of the injured muscle tissue progresses ITGB6 protein is found in newly formed fibers up to at least 15 days post-injury. Springer Netherlands 2014-02-02 2014 /pmc/articles/PMC3983900/ /pubmed/24488487 http://dx.doi.org/10.1007/s10735-014-9567-2 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Ducceschi, Melissa
Clifton, Lisa G.
Stimpson, Stephen A.
Billin, Andrew N.
Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle
title Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle
title_full Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle
title_fullStr Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle
title_full_unstemmed Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle
title_short Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle
title_sort post-transcriptional regulation of itgb6 protein levels in damaged skeletal muscle
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983900/
https://www.ncbi.nlm.nih.gov/pubmed/24488487
http://dx.doi.org/10.1007/s10735-014-9567-2
work_keys_str_mv AT ducceschimelissa posttranscriptionalregulationofitgb6proteinlevelsindamagedskeletalmuscle
AT cliftonlisag posttranscriptionalregulationofitgb6proteinlevelsindamagedskeletalmuscle
AT stimpsonstephena posttranscriptionalregulationofitgb6proteinlevelsindamagedskeletalmuscle
AT billinandrewn posttranscriptionalregulationofitgb6proteinlevelsindamagedskeletalmuscle

Ejemplares similares