Cargando…

Modulation of HIV-1 immunity by adjuvants

PURPOSE OF REVIEW: To summarize the role of adjuvants in eliciting desirable antibody responses against HIV-1 with particular emphasis on both historical context and recent developments. RECENT FINDINGS: Increased understanding of the role of pattern recognition receptors such as Toll-like receptors...

Descripción completa

Detalles Bibliográficos
Autor principal: Moody, M. Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984023/
https://www.ncbi.nlm.nih.gov/pubmed/24670321
http://dx.doi.org/10.1097/COH.0000000000000052
_version_ 1782311385396412416
author Moody, M. Anthony
author_facet Moody, M. Anthony
author_sort Moody, M. Anthony
collection PubMed
description PURPOSE OF REVIEW: To summarize the role of adjuvants in eliciting desirable antibody responses against HIV-1 with particular emphasis on both historical context and recent developments. RECENT FINDINGS: Increased understanding of the role of pattern recognition receptors such as Toll-like receptors in recruiting and directing the immune system has increased the variety of adjuvant formulations being tested in animal models and humans. Across all vaccine platforms, adjuvant formulations have been shown to enhance desirable immune responses such as higher antibody titers and increased functional activity. Although no vaccine formulation has yet succeeded in eliciting broad neutralizing antibodies against HIV-1, the ability of adjuvants to direct the immune response to immunogens suggests they will be critically important in any successful HIV-1 vaccine. SUMMARY: The parallel development of adjuvants along with better HIV-1 immunogens will be needed for a successful AIDS vaccine. Additional comparative testing will be required to determine the optimal adjuvant and immunogen regimen that can elicit antibody responses capable of blocking HIV-1 transmission.
format Online
Article
Text
id pubmed-3984023
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-39840232014-04-14 Modulation of HIV-1 immunity by adjuvants Moody, M. Anthony Curr Opin HIV AIDS SPECTRUM OF HIV ANTIBODIES IN VACCINE AND DISEASE: Edited by Georgia D. Tomaras and David C. Montefiori PURPOSE OF REVIEW: To summarize the role of adjuvants in eliciting desirable antibody responses against HIV-1 with particular emphasis on both historical context and recent developments. RECENT FINDINGS: Increased understanding of the role of pattern recognition receptors such as Toll-like receptors in recruiting and directing the immune system has increased the variety of adjuvant formulations being tested in animal models and humans. Across all vaccine platforms, adjuvant formulations have been shown to enhance desirable immune responses such as higher antibody titers and increased functional activity. Although no vaccine formulation has yet succeeded in eliciting broad neutralizing antibodies against HIV-1, the ability of adjuvants to direct the immune response to immunogens suggests they will be critically important in any successful HIV-1 vaccine. SUMMARY: The parallel development of adjuvants along with better HIV-1 immunogens will be needed for a successful AIDS vaccine. Additional comparative testing will be required to determine the optimal adjuvant and immunogen regimen that can elicit antibody responses capable of blocking HIV-1 transmission. Lippincott Williams & Wilkins 2014-05 2014-04-10 /pmc/articles/PMC3984023/ /pubmed/24670321 http://dx.doi.org/10.1097/COH.0000000000000052 Text en © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle SPECTRUM OF HIV ANTIBODIES IN VACCINE AND DISEASE: Edited by Georgia D. Tomaras and David C. Montefiori
Moody, M. Anthony
Modulation of HIV-1 immunity by adjuvants
title Modulation of HIV-1 immunity by adjuvants
title_full Modulation of HIV-1 immunity by adjuvants
title_fullStr Modulation of HIV-1 immunity by adjuvants
title_full_unstemmed Modulation of HIV-1 immunity by adjuvants
title_short Modulation of HIV-1 immunity by adjuvants
title_sort modulation of hiv-1 immunity by adjuvants
topic SPECTRUM OF HIV ANTIBODIES IN VACCINE AND DISEASE: Edited by Georgia D. Tomaras and David C. Montefiori
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984023/
https://www.ncbi.nlm.nih.gov/pubmed/24670321
http://dx.doi.org/10.1097/COH.0000000000000052
work_keys_str_mv AT moodymanthony modulationofhiv1immunitybyadjuvants