Adeno-associated virus type 8 vector–mediated expression of siRNA targeting vascular endothelial growth factor efficiently inhibits neovascularization in a murine choroidal neovascularization model

PURPOSE: To assess the feasibility of a gene therapeutic approach to treating choroidal neovascularization (CNV), we generated an adeno-associated virus type 8 vector (AAV2/8) encoding an siRNA targeting vascular endothelial growth factor (VEGF), and determined the AAV2/8 vector’s ability to inhibit...

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Detalles Bibliográficos
Autores principales: Igarashi, Tsutomu, Miyake, Noriko, Fujimoto, Chiaki, Yaguchi, Chiemi, Iijima, Osamu, Shimada, Takashi, Takahashi, Hiroshi, Miyake, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984039/
https://www.ncbi.nlm.nih.gov/pubmed/24744609

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