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Cigarette smoking and colorectal cancer mortality among 602,242 Norwegian males and females

BACKGROUND: Colorectal cancer (CRC) is one of the main cancer types, with high incidence and mortality in Norway. We examined the association between different measures of smoking exposure and CRC mortality overall and by subsite in a large Norwegian cohort. METHODS: We followed 602,242 participants...

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Autores principales: Parajuli, Ranjan, Bjerkaas, Eivind, Tverdal, Aage, Le Marchand, Loïc, Weiderpass, Elisabete, Gram, Inger T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984060/
https://www.ncbi.nlm.nih.gov/pubmed/24741327
http://dx.doi.org/10.2147/CLEP.S58722
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author Parajuli, Ranjan
Bjerkaas, Eivind
Tverdal, Aage
Le Marchand, Loïc
Weiderpass, Elisabete
Gram, Inger T
author_facet Parajuli, Ranjan
Bjerkaas, Eivind
Tverdal, Aage
Le Marchand, Loïc
Weiderpass, Elisabete
Gram, Inger T
author_sort Parajuli, Ranjan
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) is one of the main cancer types, with high incidence and mortality in Norway. We examined the association between different measures of smoking exposure and CRC mortality overall and by subsite in a large Norwegian cohort. METHODS: We followed 602,242 participants from four Norwegian health surveys, aged 19–67 years at enrollment between 1972 and 2003 by linkage to the national registries through December 2007. We used Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) by smoking categories for different CRC endpoints. RESULTS: During a mean follow-up of 14 years, 2,333 Norwegian males and females died of CRC (60% men). Male and female ever smokers had a 20% (HR 1.23, CI 1.08–1.40 and HR 1.22, 95% CI 1.06–1.40, respectively) increased risk of death from CRC compared with sex-specific never smokers. For proximal colon cancer mortality, female ever smokers had a 50% (HR 1.49, 95% CI 1.20–1.87) increased risk compared with female never smokers. The increased risk of rectal cancer mortality was about 40% higher for male ever smokers (HR 1.43, 95% CI 1.14–1.81) compared with male never smokers. A test for heterogeneity by sex showed an increased risk of rectal cancer mortality among men which was significant for former smokers (Wald χ(2)=0.02) and an increased risk of proximal colon cancer mortality among women which was significant for ever and former smokers (Wald χ(2)=0.02 and χ(2)=0.04, respectively). CONCLUSION: Smoking is associated with increased CRC mortality in both sexes. The risk of rectal and proximal colon cancer mortality was most pronounced among male and female smokers respectively.
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spelling pubmed-39840602014-04-16 Cigarette smoking and colorectal cancer mortality among 602,242 Norwegian males and females Parajuli, Ranjan Bjerkaas, Eivind Tverdal, Aage Le Marchand, Loïc Weiderpass, Elisabete Gram, Inger T Clin Epidemiol Original Research BACKGROUND: Colorectal cancer (CRC) is one of the main cancer types, with high incidence and mortality in Norway. We examined the association between different measures of smoking exposure and CRC mortality overall and by subsite in a large Norwegian cohort. METHODS: We followed 602,242 participants from four Norwegian health surveys, aged 19–67 years at enrollment between 1972 and 2003 by linkage to the national registries through December 2007. We used Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) by smoking categories for different CRC endpoints. RESULTS: During a mean follow-up of 14 years, 2,333 Norwegian males and females died of CRC (60% men). Male and female ever smokers had a 20% (HR 1.23, CI 1.08–1.40 and HR 1.22, 95% CI 1.06–1.40, respectively) increased risk of death from CRC compared with sex-specific never smokers. For proximal colon cancer mortality, female ever smokers had a 50% (HR 1.49, 95% CI 1.20–1.87) increased risk compared with female never smokers. The increased risk of rectal cancer mortality was about 40% higher for male ever smokers (HR 1.43, 95% CI 1.14–1.81) compared with male never smokers. A test for heterogeneity by sex showed an increased risk of rectal cancer mortality among men which was significant for former smokers (Wald χ(2)=0.02) and an increased risk of proximal colon cancer mortality among women which was significant for ever and former smokers (Wald χ(2)=0.02 and χ(2)=0.04, respectively). CONCLUSION: Smoking is associated with increased CRC mortality in both sexes. The risk of rectal and proximal colon cancer mortality was most pronounced among male and female smokers respectively. Dove Medical Press 2014-04-07 /pmc/articles/PMC3984060/ /pubmed/24741327 http://dx.doi.org/10.2147/CLEP.S58722 Text en © 2014 Parajuli et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Parajuli, Ranjan
Bjerkaas, Eivind
Tverdal, Aage
Le Marchand, Loïc
Weiderpass, Elisabete
Gram, Inger T
Cigarette smoking and colorectal cancer mortality among 602,242 Norwegian males and females
title Cigarette smoking and colorectal cancer mortality among 602,242 Norwegian males and females
title_full Cigarette smoking and colorectal cancer mortality among 602,242 Norwegian males and females
title_fullStr Cigarette smoking and colorectal cancer mortality among 602,242 Norwegian males and females
title_full_unstemmed Cigarette smoking and colorectal cancer mortality among 602,242 Norwegian males and females
title_short Cigarette smoking and colorectal cancer mortality among 602,242 Norwegian males and females
title_sort cigarette smoking and colorectal cancer mortality among 602,242 norwegian males and females
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984060/
https://www.ncbi.nlm.nih.gov/pubmed/24741327
http://dx.doi.org/10.2147/CLEP.S58722
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