Dichloroacetate Enhances Adriamycin-Induced Hepatoma Cell Toxicity In Vitro and In Vivo by Increasing Reactive Oxygen Species Levels

A unique bioenergetic feature of cancer, aerobic glycolysis is considered an attractive therapeutic target for cancer therapy. Recently, dichloroacetate (DCA), a small-molecule metabolic modulator, was shown to reverse the glycolytic phenotype, induce reactive oxygen species (ROS) generation, and tr...

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Detalles Bibliográficos
Autores principales: Dai, Yunhai, Xiong, Xiaopeng, Huang, Gang, Liu, Jianjun, Sheng, Shile, Wang, Hongjian, Qin, Wenxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984074/
https://www.ncbi.nlm.nih.gov/pubmed/24728083
http://dx.doi.org/10.1371/journal.pone.0092962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984074/
https://www.ncbi.nlm.nih.gov/pubmed/24728083
http://dx.doi.org/10.1371/journal.pone.0092962

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