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Dichloroacetate Enhances Adriamycin-Induced Hepatoma Cell Toxicity In Vitro and In Vivo by Increasing Reactive Oxygen Species Levels

A unique bioenergetic feature of cancer, aerobic glycolysis is considered an attractive therapeutic target for cancer therapy. Recently, dichloroacetate (DCA), a small-molecule metabolic modulator, was shown to reverse the glycolytic phenotype, induce reactive oxygen species (ROS) generation, and tr...

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Detalles Bibliográficos
Autores principales:	Dai, Yunhai, Xiong, Xiaopeng, Huang, Gang, Liu, Jianjun, Sheng, Shile, Wang, Hongjian, Qin, Wenxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984074/ https://www.ncbi.nlm.nih.gov/pubmed/24728083 http://dx.doi.org/10.1371/journal.pone.0092962

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