Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer

BACKGROUND: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. METHODS: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their associ...

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Autores principales: Sanoff, Hanna K., Renfro, Lindsay A., Poonnen, Pradeep, Ambadwar, Pratibha, Sargent, Daniel J., Goldberg, Richard M., McLeod, Howard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984266/
https://www.ncbi.nlm.nih.gov/pubmed/24727911
http://dx.doi.org/10.1371/journal.pone.0094727
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author Sanoff, Hanna K.
Renfro, Lindsay A.
Poonnen, Pradeep
Ambadwar, Pratibha
Sargent, Daniel J.
Goldberg, Richard M.
McLeod, Howard
author_facet Sanoff, Hanna K.
Renfro, Lindsay A.
Poonnen, Pradeep
Ambadwar, Pratibha
Sargent, Daniel J.
Goldberg, Richard M.
McLeod, Howard
author_sort Sanoff, Hanna K.
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. METHODS: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC. RESULTS: rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS). CONCLUSION: Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC.
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spelling pubmed-39842662014-04-15 Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer Sanoff, Hanna K. Renfro, Lindsay A. Poonnen, Pradeep Ambadwar, Pratibha Sargent, Daniel J. Goldberg, Richard M. McLeod, Howard PLoS One Research Article BACKGROUND: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. METHODS: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC. RESULTS: rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS). CONCLUSION: Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC. Public Library of Science 2014-04-11 /pmc/articles/PMC3984266/ /pubmed/24727911 http://dx.doi.org/10.1371/journal.pone.0094727 Text en © 2014 Sanoff et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sanoff, Hanna K.
Renfro, Lindsay A.
Poonnen, Pradeep
Ambadwar, Pratibha
Sargent, Daniel J.
Goldberg, Richard M.
McLeod, Howard
Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer
title Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer
title_full Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer
title_fullStr Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer
title_full_unstemmed Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer
title_short Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer
title_sort germline variation in colorectal risk loci does not influence treatment effect or survival in metastatic colorectal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984266/
https://www.ncbi.nlm.nih.gov/pubmed/24727911
http://dx.doi.org/10.1371/journal.pone.0094727
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