Cargando…

Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer

BACKGROUND: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. METHODS: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their associ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sanoff, Hanna K., Renfro, Lindsay A., Poonnen, Pradeep, Ambadwar, Pratibha, Sargent, Daniel J., Goldberg, Richard M., McLeod, Howard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984266/ https://www.ncbi.nlm.nih.gov/pubmed/24727911 http://dx.doi.org/10.1371/journal.pone.0094727

Ejemplares similares

Germline Profiling and Molecular Characterization of Early Onset Metastatic Colorectal Cancer
por: Xu, Ting, et al.
Publicado: (2020)

Association of Eleven Common, Low-Penetrance Colorectal Cancer Susceptibility Genetic Variants at Six Risk Loci with Clinical Outcome
por: Hoskins, Janelle M., et al.
Publicado: (2012)

Tumour markers of prognosis in colorectal cancer
por: McLeod, H L, et al.
Publicado: (1999)

Does a transition to accountable care in Medicaid shift the modality of colorectal cancer testing?
por: Davis, Melinda M., et al.
Publicado: (2019)

Low-frequency variation near common germline susceptibility loci are associated with risk of Ewing sarcoma
por: Lin, Shu-Hong, et al.
Publicado: (2020)

Co-Occurrence of Germline Genomic Variants and Copy Number Variations in Hereditary Breast and Colorectal Cancer Patients
por: Côrtes, Luiza, et al.
Publicado: (2023)

MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients
por: Gonzalez, Ricardo D., et al.
Publicado: (2023)

Metastatic Colorectal Cancer
por: Passardi, Alessandro, et al.
Publicado: (2021)

Genetic insights: High germline variant rate in an indigenous African cohort with early-onset colorectal cancer
por: Yildiz, Safiye, et al.
Publicado: (2023)

Germline Polymorphisms in the Nuclear Receptors PXR and VDR as Novel Prognostic Markers in Metastatic Colorectal Cancer Patients Treated With FOLFIRI
por: De Mattia, Elena, et al.
Publicado: (2019)

Germline EPHB2 Receptor Variants in Familial Colorectal Cancer
por: Zogopoulos, George, et al.
Publicado: (2008)

Mitogenome germline mutations and colorectal cancer risk in Polish population
por: Skonieczna, Katarzyna, et al.
Publicado: (2019)

Heterozygous APC germline mutations impart predisposition to colorectal cancer
por: Preisler, Livia, et al.
Publicado: (2021)

Association between germline variants and somatic mutations in colorectal cancer
por: Barfield, Richard, et al.
Publicado: (2022)

Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer?
por: Derangère, Valentin, et al.
Publicado: (2016)

Utility of the quasi‐monomorphic variation range in unresectable metastatic colorectal cancer patients
por: Bando, Hideaki, et al.
Publicado: (2018)

Baseline Quality of Life is a Strong and Independent Prognostic Factor for Overall Survival in Metastatic Colorectal Cancer
por: McGarrah, Patrick, et al.
Publicado: (2023)

Germline variability and tumor expression level of ribosomal protein gene RPL28 are associated with survival of metastatic colorectal cancer patients
por: Labriet, Adrien, et al.
Publicado: (2019)

Cancer Genomic Profiling in Colorectal Cancer: Current Challenges in Subtyping Colorectal Cancers Based on Somatic and Germline Variants
por: Hinoi, Takao
Publicado: (2021)

Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease
por: Murphy, Caitlin C., et al.
Publicado: (2017)

The Challenge of Metastatic Colorectal Cancer
por: Cidón, Esther Uña
Publicado: (2010)

Metastatic components in colorectal cancer
por: Javarsiani, Marjan Hajimoradi, et al.
Publicado: (2019)

Markers of metastatic colorectal cancer
por: Myśliwiec, Piotr, et al.
Publicado: (2019)

Unfavourable expression of pharmacologic markers in mucinous colorectal cancer
por: Glasgow, S C, et al.
Publicado: (2005)

RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer
por: Church, R D, et al.
Publicado: (2004)

EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis
por: Kokko, Antti, et al.
Publicado: (2006)

Evaluation of Germline BMP4 Mutation as a Cause of Colorectal Cancer
por: Lubbe, Steven J, et al.
Publicado: (2011)

Deleterious Germline BLM Mutations and the Risk for Early-onset Colorectal Cancer
por: de Voer, Richarda M., et al.
Publicado: (2015)

Germline miRNA DNA variants and the risk of colorectal cancer by subtype
por: Lindor, Noralane M., et al.
Publicado: (2016)

Germline Variants of CYBA and TRPM4 Predispose to Familial Colorectal Cancer
por: Zhu, Lizhen, et al.
Publicado: (2022)

Genome wide association identified colorectal cancer susceptibility loci and colorectal cancer risk in Lynch syndrome
por: Pande, Mala, et al.
Publicado: (2010)

Joint Effects of Colorectal Cancer Susceptibility Loci, Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer
por: Hiraki, Linda T., et al.
Publicado: (2014)

ABC-Transporter Expression Does Not Correlate with Response to Irinotecan in Patients with Metastatic Colorectal Cancer
por: Trumpi, K., et al.
Publicado: (2015)

Association studies on 11 published colorectal cancer risk loci
por: von Holst, S, et al.
Publicado: (2010)

Identification of specific susceptibility loci for the early-onset colorectal cancer
por: Wang, Haoxue, et al.
Publicado: (2023)

Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours.
por: McLeod, H. L., et al.
Publicado: (1998)

Optimising the use of cetuximab in the continuum of care for patients with metastatic colorectal cancer
por: Goldberg, Richard M, et al.
Publicado: (2018)

Risk of colorectal cancer for carriers of a germline mutation in POLE or POLD1
por: Buchanan, Daniel D., et al.
Publicado: (2017)

Case Report: Coinheritance of Germline Mutations in APC and BRCA1 in Colorectal Cancer
por: Huang, Wei, et al.
Publicado: (2021)

Germline mutations in a DNA repair pathway are associated with familial colorectal cancer
por: Xu, Pingping, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i06psdseui360krfgdr5rttd01