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Incidence of Active Pulmonary Tuberculosis in Patients with Coincident Filarial and/or Intestinal Helminth Infections Followed Longitudinally in South India

BACKGROUND: Filarial (and other helminth) infections are known to modulate mycobacteria-specific pro-inflammatory cytokine responses necessary for maintaining latency in tuberculosis (TB). We sought to address whether helminth co-infection alters progression to active pulmonary TB in a co-endemic ar...

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Autores principales: Chatterjee, Soumya, Kolappan, Chockalingam, Subramani, Rangasamy, Gopi, Punnathanathu G., Chandrasekaran, Vedhachalam, Fay, Michael P., Babu, Subash, Kumaraswami, Vasanthapuram, Nutman, Thomas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984271/
https://www.ncbi.nlm.nih.gov/pubmed/24728010
http://dx.doi.org/10.1371/journal.pone.0094603
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author Chatterjee, Soumya
Kolappan, Chockalingam
Subramani, Rangasamy
Gopi, Punnathanathu G.
Chandrasekaran, Vedhachalam
Fay, Michael P.
Babu, Subash
Kumaraswami, Vasanthapuram
Nutman, Thomas B.
author_facet Chatterjee, Soumya
Kolappan, Chockalingam
Subramani, Rangasamy
Gopi, Punnathanathu G.
Chandrasekaran, Vedhachalam
Fay, Michael P.
Babu, Subash
Kumaraswami, Vasanthapuram
Nutman, Thomas B.
author_sort Chatterjee, Soumya
collection PubMed
description BACKGROUND: Filarial (and other helminth) infections are known to modulate mycobacteria-specific pro-inflammatory cytokine responses necessary for maintaining latency in tuberculosis (TB). We sought to address whether helminth co-infection alters progression to active pulmonary TB in a co-endemic area of South India. METHODS/PRINCIPAL FINDINGS: Incidence of active pulmonary TB was assessed in 5096 subjects from five villages among helminth-infected (hel(+)) and –uninfected (hel(−)) groups. Baseline stool examinations, circulating filarial antigen, and tuberculin skin testing (PPD) were performed along with chest radiographs, sputum microscopy, and culture. During three follow-up visits each 2.5 years, patients were assessed using PPD tests and questionnaires and—for those with potential symptoms of TB—sputum microscopy and culture. Of the 5096 subjects, 1923 were found to be hel(+) and 3173 were hel(−). Follow up interval stool examination could not be performed. In each group, 21 developed active TB over the course of the study. After adjusting for sex, age, BCG vaccination status, and PPD positivity, no difference was seen in active TB incidence between hel(+) and hel(−) groups either at baseline (relative risk (RR) 1.60; 95% confidence interval (CI): 0.69, 3.71, P = 0·27), or when followed prospectively (RR 1.24; 95% CI: 0.48, 3.18, P = 0·66). CONCLUSIONS/SIGNIFICANCE: Our findings suggest that, despite the immunomodulatory effects of helminth infection, baseline co-morbid infection with these parasites had little effect on the clinical progression from latent to active pulmonary TB.
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spelling pubmed-39842712014-04-15 Incidence of Active Pulmonary Tuberculosis in Patients with Coincident Filarial and/or Intestinal Helminth Infections Followed Longitudinally in South India Chatterjee, Soumya Kolappan, Chockalingam Subramani, Rangasamy Gopi, Punnathanathu G. Chandrasekaran, Vedhachalam Fay, Michael P. Babu, Subash Kumaraswami, Vasanthapuram Nutman, Thomas B. PLoS One Research Article BACKGROUND: Filarial (and other helminth) infections are known to modulate mycobacteria-specific pro-inflammatory cytokine responses necessary for maintaining latency in tuberculosis (TB). We sought to address whether helminth co-infection alters progression to active pulmonary TB in a co-endemic area of South India. METHODS/PRINCIPAL FINDINGS: Incidence of active pulmonary TB was assessed in 5096 subjects from five villages among helminth-infected (hel(+)) and –uninfected (hel(−)) groups. Baseline stool examinations, circulating filarial antigen, and tuberculin skin testing (PPD) were performed along with chest radiographs, sputum microscopy, and culture. During three follow-up visits each 2.5 years, patients were assessed using PPD tests and questionnaires and—for those with potential symptoms of TB—sputum microscopy and culture. Of the 5096 subjects, 1923 were found to be hel(+) and 3173 were hel(−). Follow up interval stool examination could not be performed. In each group, 21 developed active TB over the course of the study. After adjusting for sex, age, BCG vaccination status, and PPD positivity, no difference was seen in active TB incidence between hel(+) and hel(−) groups either at baseline (relative risk (RR) 1.60; 95% confidence interval (CI): 0.69, 3.71, P = 0·27), or when followed prospectively (RR 1.24; 95% CI: 0.48, 3.18, P = 0·66). CONCLUSIONS/SIGNIFICANCE: Our findings suggest that, despite the immunomodulatory effects of helminth infection, baseline co-morbid infection with these parasites had little effect on the clinical progression from latent to active pulmonary TB. Public Library of Science 2014-04-11 /pmc/articles/PMC3984271/ /pubmed/24728010 http://dx.doi.org/10.1371/journal.pone.0094603 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Chatterjee, Soumya
Kolappan, Chockalingam
Subramani, Rangasamy
Gopi, Punnathanathu G.
Chandrasekaran, Vedhachalam
Fay, Michael P.
Babu, Subash
Kumaraswami, Vasanthapuram
Nutman, Thomas B.
Incidence of Active Pulmonary Tuberculosis in Patients with Coincident Filarial and/or Intestinal Helminth Infections Followed Longitudinally in South India
title Incidence of Active Pulmonary Tuberculosis in Patients with Coincident Filarial and/or Intestinal Helminth Infections Followed Longitudinally in South India
title_full Incidence of Active Pulmonary Tuberculosis in Patients with Coincident Filarial and/or Intestinal Helminth Infections Followed Longitudinally in South India
title_fullStr Incidence of Active Pulmonary Tuberculosis in Patients with Coincident Filarial and/or Intestinal Helminth Infections Followed Longitudinally in South India
title_full_unstemmed Incidence of Active Pulmonary Tuberculosis in Patients with Coincident Filarial and/or Intestinal Helminth Infections Followed Longitudinally in South India
title_short Incidence of Active Pulmonary Tuberculosis in Patients with Coincident Filarial and/or Intestinal Helminth Infections Followed Longitudinally in South India
title_sort incidence of active pulmonary tuberculosis in patients with coincident filarial and/or intestinal helminth infections followed longitudinally in south india
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984271/
https://www.ncbi.nlm.nih.gov/pubmed/24728010
http://dx.doi.org/10.1371/journal.pone.0094603
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