Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes

Modifications like asparagine deamidation, aspartate isomerization, methionine oxidation, and lysine glycation are typical degradations for recombinant antibodies. For the identification and functional evaluation of antibody critical quality attributes (CQAs) derived from chemical modifications in t...

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Detalles Bibliográficos
Autores principales: Haberger, Markus, Bomans, Katrin, Diepold, Katharina, Hook, Michaela, Gassner, Jana, Schlothauer, Tilman, Zwick, Adrian, Spick, Christian, Kepert, Jochen Felix, Hienz, Brigitte, Wiedmann, Michael, Beck, Hermann, Metzger, Philipp, Mølhøj, Michael, Knoblich, Constanze, Grauschopf, Ulla, Reusch, Dietmar, Bulau, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984323/
https://www.ncbi.nlm.nih.gov/pubmed/24441081
http://dx.doi.org/10.4161/mabs.27876

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