3D modeling and characterization of the human CD115 monoclonal antibody H27K15 epitope and design of a chimeric CD115 target

The humanized monoclonal antibody H27K15 specifically targets human CD115, a type III tyrosine kinase receptor involved in multiple cancers and inflammatory diseases. Binding of H27K15 to hCD115 expressing cells inhibits the functional effect of colony-stimulating factor-1 (CSF-1), in a non-competit...

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Detalles Bibliográficos
Autores principales: Grellier, Benoît, Le Pogam, Fabrice, Vitorino, Marc, Starck, Jean-Philippe, Geist, Michel, Duong, Vanessa, Haegel, Hélène, Menguy, Thierry, Bonnefoy, Jean-Yves, Marchand, Jean-Baptiste, Ancian, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984341/
https://www.ncbi.nlm.nih.gov/pubmed/24492308
http://dx.doi.org/10.4161/mabs.27736

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