Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

Recent studies have propagated the model that the mitochondrial unfolded protein response (UPR(mt)) is causal for lifespan extension from inhibition of the electron transport chain (ETC) in C. elegans. Here we report a genome-wide RNAi screen for negative regulators of the UPR(mt). Lifespan analysis...

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Detalles Bibliográficos
Autores principales: Bennett, Christopher F., Wende, Helen Vander, Simko, Marissa, Klum, Shannon, Barfield, Sarah, Choi, Haeri, Pineda, Victor V., Kaeberlein, Matt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984390/
https://www.ncbi.nlm.nih.gov/pubmed/24662282
http://dx.doi.org/10.1038/ncomms4483

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