Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery

Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associated with many diseases. It is especially critical to develop the rapid and sensitive methods...

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Autores principales: Liu, Huan, Zhang, Ningbo, Wan, Debin, Cui, Meng, Liu, Zhiqiang, Liu, Shuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984494/
https://www.ncbi.nlm.nih.gov/pubmed/24722010
http://dx.doi.org/10.1186/1559-0275-11-14
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author Liu, Huan
Zhang, Ningbo
Wan, Debin
Cui, Meng
Liu, Zhiqiang
Liu, Shuying
author_facet Liu, Huan
Zhang, Ningbo
Wan, Debin
Cui, Meng
Liu, Zhiqiang
Liu, Shuying
author_sort Liu, Huan
collection PubMed
description Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associated with many diseases. It is especially critical to develop the rapid and sensitive methods for analysis of aberrant glycoproteins associated with diseases. Mass spectrometry (MS) has become a powerful tool for glycoprotein analysis. Especially, tandem mass spectrometry can provide highly informative fragments for structural identification of glycoproteins. This review provides an overview of the development of MS technologies and their applications in identification of abnormal glycoproteins and glycans in human serum to screen cancer biomarkers in recent years.
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spelling pubmed-39844942014-04-17 Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery Liu, Huan Zhang, Ningbo Wan, Debin Cui, Meng Liu, Zhiqiang Liu, Shuying Clin Proteomics Review Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associated with many diseases. It is especially critical to develop the rapid and sensitive methods for analysis of aberrant glycoproteins associated with diseases. Mass spectrometry (MS) has become a powerful tool for glycoprotein analysis. Especially, tandem mass spectrometry can provide highly informative fragments for structural identification of glycoproteins. This review provides an overview of the development of MS technologies and their applications in identification of abnormal glycoproteins and glycans in human serum to screen cancer biomarkers in recent years. Springer 2014-04-10 /pmc/articles/PMC3984494/ /pubmed/24722010 http://dx.doi.org/10.1186/1559-0275-11-14 Text en Copyright © 2014 Liu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Liu, Huan
Zhang, Ningbo
Wan, Debin
Cui, Meng
Liu, Zhiqiang
Liu, Shuying
Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery
title Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery
title_full Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery
title_fullStr Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery
title_full_unstemmed Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery
title_short Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery
title_sort mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984494/
https://www.ncbi.nlm.nih.gov/pubmed/24722010
http://dx.doi.org/10.1186/1559-0275-11-14
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