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Laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis?

Rheumatoid arthritis (RA) is a common autoimmune disease in which a heterogeneous course and different pathogenic mechanisms are implicated in chronic inflammation and joint destruction. Despite the diagnostic contribution of anti-citrullinated protein/peptide antibodies (ACPAs) and rheumatoid facto...

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Autores principales: Šenolt, Ladislav, Grassi, Walter, Szodoray, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984686/
https://www.ncbi.nlm.nih.gov/pubmed/24642071
http://dx.doi.org/10.1186/1741-7015-12-49
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author Šenolt, Ladislav
Grassi, Walter
Szodoray, Peter
author_facet Šenolt, Ladislav
Grassi, Walter
Szodoray, Peter
author_sort Šenolt, Ladislav
collection PubMed
description Rheumatoid arthritis (RA) is a common autoimmune disease in which a heterogeneous course and different pathogenic mechanisms are implicated in chronic inflammation and joint destruction. Despite the diagnostic contribution of anti-citrullinated protein/peptide antibodies (ACPAs) and rheumatoid factors, about one-third of RA patients remain seronegative. ACPAs belong to a heterogeneous family of autoantibodies targeting citrullinated proteins, including myelin-basic protein, several histone proteins, filaggrin and fibrin, fibrinogen or vimentin. In addition to ACPAs, antibodies directed against other post-translationally modified-carbamylated proteins (anti-CarP) were detected in up to 30% of ACPA-negative patients. Using phage display technology, further autoantibodies were recently discovered as candidate biomarkers for seronegative RA patients. Furthermore, in clinical practice, ultrasound may reveal subclinical synovitis and radiographically undetected bone erosions. To improve diagnostic certainty in undifferentiated arthritis and seronegative patients, ultrasound imaging and several new biomarkers may help to identify at risk patients and those with early disease. In this commentary we summarize recent advances in joint ultrasound and future potential of serological biomarkers to improve diagnosis of RA.
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spelling pubmed-39846862014-04-14 Laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis? Šenolt, Ladislav Grassi, Walter Szodoray, Peter BMC Med Commentary Rheumatoid arthritis (RA) is a common autoimmune disease in which a heterogeneous course and different pathogenic mechanisms are implicated in chronic inflammation and joint destruction. Despite the diagnostic contribution of anti-citrullinated protein/peptide antibodies (ACPAs) and rheumatoid factors, about one-third of RA patients remain seronegative. ACPAs belong to a heterogeneous family of autoantibodies targeting citrullinated proteins, including myelin-basic protein, several histone proteins, filaggrin and fibrin, fibrinogen or vimentin. In addition to ACPAs, antibodies directed against other post-translationally modified-carbamylated proteins (anti-CarP) were detected in up to 30% of ACPA-negative patients. Using phage display technology, further autoantibodies were recently discovered as candidate biomarkers for seronegative RA patients. Furthermore, in clinical practice, ultrasound may reveal subclinical synovitis and radiographically undetected bone erosions. To improve diagnostic certainty in undifferentiated arthritis and seronegative patients, ultrasound imaging and several new biomarkers may help to identify at risk patients and those with early disease. In this commentary we summarize recent advances in joint ultrasound and future potential of serological biomarkers to improve diagnosis of RA. BioMed Central 2014-03-18 /pmc/articles/PMC3984686/ /pubmed/24642071 http://dx.doi.org/10.1186/1741-7015-12-49 Text en Copyright © 2014 ¿enolt et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Šenolt, Ladislav
Grassi, Walter
Szodoray, Peter
Laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis?
title Laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis?
title_full Laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis?
title_fullStr Laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis?
title_full_unstemmed Laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis?
title_short Laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis?
title_sort laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984686/
https://www.ncbi.nlm.nih.gov/pubmed/24642071
http://dx.doi.org/10.1186/1741-7015-12-49
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