Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity

BACKGROUND: This work aimed to synthesize a cathepsin B (CTSB)-cleavable tumor-targeting prodrug peptide doxorubicin (PDOX) and study the in vivo efficacy and toxicities on an animal model of gastric peritoneal carcinomatosis (PC). METHODS: PDOX was synthesized using doxorubicin (DOX) attaching to a...

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Detalles Bibliográficos
Autores principales: Tang, Li, Duan, Rui, Zhong, Yan-jun, Firestone, Raymond A, Hong, Ya-ping, Li, Ji-guo, Xin, Yan-chao, Wu, Han-lin, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984748/
https://www.ncbi.nlm.nih.gov/pubmed/24588871
http://dx.doi.org/10.1186/1476-4598-13-44

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