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A Two-Stage Exon Recognition Model Based on Synergetic Neural Network
Exon recognition is a fundamental task in bioinformatics to identify the exons of DNA sequence. Currently, exon recognition algorithms based on digital signal processing techniques have been widely used. Unfortunately, these methods require many calculations, resulting in low recognition efficiency....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984832/ https://www.ncbi.nlm.nih.gov/pubmed/24790638 http://dx.doi.org/10.1155/2014/503132 |
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author | Huang, Zhehuang Chen, Yidong |
author_facet | Huang, Zhehuang Chen, Yidong |
author_sort | Huang, Zhehuang |
collection | PubMed |
description | Exon recognition is a fundamental task in bioinformatics to identify the exons of DNA sequence. Currently, exon recognition algorithms based on digital signal processing techniques have been widely used. Unfortunately, these methods require many calculations, resulting in low recognition efficiency. In order to overcome this limitation, a two-stage exon recognition model is proposed and implemented in this paper. There are three main works. Firstly, we use synergetic neural network to rapidly determine initial exon intervals. Secondly, adaptive sliding window is used to accurately discriminate the final exon intervals. Finally, parameter optimization based on artificial fish swarm algorithm is used to determine different species thresholds and corresponding adjustment parameters of adaptive windows. Experimental results show that the proposed model has better performance for exon recognition and provides a practical solution and a promising future for other recognition tasks. |
format | Online Article Text |
id | pubmed-3984832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39848322014-04-30 A Two-Stage Exon Recognition Model Based on Synergetic Neural Network Huang, Zhehuang Chen, Yidong Comput Math Methods Med Research Article Exon recognition is a fundamental task in bioinformatics to identify the exons of DNA sequence. Currently, exon recognition algorithms based on digital signal processing techniques have been widely used. Unfortunately, these methods require many calculations, resulting in low recognition efficiency. In order to overcome this limitation, a two-stage exon recognition model is proposed and implemented in this paper. There are three main works. Firstly, we use synergetic neural network to rapidly determine initial exon intervals. Secondly, adaptive sliding window is used to accurately discriminate the final exon intervals. Finally, parameter optimization based on artificial fish swarm algorithm is used to determine different species thresholds and corresponding adjustment parameters of adaptive windows. Experimental results show that the proposed model has better performance for exon recognition and provides a practical solution and a promising future for other recognition tasks. Hindawi Publishing Corporation 2014 2014-03-25 /pmc/articles/PMC3984832/ /pubmed/24790638 http://dx.doi.org/10.1155/2014/503132 Text en Copyright © 2014 Z. Huang and Y. Chen. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Huang, Zhehuang Chen, Yidong A Two-Stage Exon Recognition Model Based on Synergetic Neural Network |
title | A Two-Stage Exon Recognition Model Based on Synergetic Neural Network |
title_full | A Two-Stage Exon Recognition Model Based on Synergetic Neural Network |
title_fullStr | A Two-Stage Exon Recognition Model Based on Synergetic Neural Network |
title_full_unstemmed | A Two-Stage Exon Recognition Model Based on Synergetic Neural Network |
title_short | A Two-Stage Exon Recognition Model Based on Synergetic Neural Network |
title_sort | two-stage exon recognition model based on synergetic neural network |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984832/ https://www.ncbi.nlm.nih.gov/pubmed/24790638 http://dx.doi.org/10.1155/2014/503132 |
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