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Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins
The HSP90 molecular chaperone plays a key role in the maturation, stability and activation of its clients, including many oncogenic proteins. Kinases are a substantial and important subset of clients requiring the key cochaperone CDC37. We sought an improved understanding of protein kinase chaperoni...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984902/ https://www.ncbi.nlm.nih.gov/pubmed/24292678 http://dx.doi.org/10.1038/onc.2013.519 |