Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates

IGFBP-2 (1) has been described as a brain tumor oncogene (2) and is widely expressed in cancers from different origins (3–8). IGFBP-2 alone cannot cause malignant transformation, yet progression of brain tumors to higher grade (9) and also has been provided as a protective element in earlier stages...

Descripción completa

Detalles Bibliográficos
Autores principales: Hoeflich, Andreas, Wirthgen, Elisa, David, Robert, Classen, Carl Friedrich, Spitschak, Marion, Brenmoehl, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985015/
https://www.ncbi.nlm.nih.gov/pubmed/24778626
http://dx.doi.org/10.3389/fendo.2014.00043
_version_ 1782311520243286016
author Hoeflich, Andreas
Wirthgen, Elisa
David, Robert
Classen, Carl Friedrich
Spitschak, Marion
Brenmoehl, Julia
author_facet Hoeflich, Andreas
Wirthgen, Elisa
David, Robert
Classen, Carl Friedrich
Spitschak, Marion
Brenmoehl, Julia
author_sort Hoeflich, Andreas
collection PubMed
description IGFBP-2 (1) has been described as a brain tumor oncogene (2) and is widely expressed in cancers from different origins (3–8). IGFBP-2 alone cannot cause malignant transformation, yet progression of brain tumors to higher grade (9) and also has been provided as a protective element in earlier stages of multistage colon carcinogenesis (10). Therefore, it is crucial to understand the factors that determine expression patterns of IGFBP-2 under normal and malignant conditions. The present review provides a comprehensive update of known factors that have an impact on expression of IGFBP-2.
format Online
Article
Text
id pubmed-3985015
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-39850152014-04-28 Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates Hoeflich, Andreas Wirthgen, Elisa David, Robert Classen, Carl Friedrich Spitschak, Marion Brenmoehl, Julia Front Endocrinol (Lausanne) Endocrinology IGFBP-2 (1) has been described as a brain tumor oncogene (2) and is widely expressed in cancers from different origins (3–8). IGFBP-2 alone cannot cause malignant transformation, yet progression of brain tumors to higher grade (9) and also has been provided as a protective element in earlier stages of multistage colon carcinogenesis (10). Therefore, it is crucial to understand the factors that determine expression patterns of IGFBP-2 under normal and malignant conditions. The present review provides a comprehensive update of known factors that have an impact on expression of IGFBP-2. Frontiers Media S.A. 2014-04-07 /pmc/articles/PMC3985015/ /pubmed/24778626 http://dx.doi.org/10.3389/fendo.2014.00043 Text en Copyright © 2014 Hoeflich, Wirthgen, David, Classen, Spitschak and Brenmoehl. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Hoeflich, Andreas
Wirthgen, Elisa
David, Robert
Classen, Carl Friedrich
Spitschak, Marion
Brenmoehl, Julia
Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates
title Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates
title_full Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates
title_fullStr Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates
title_full_unstemmed Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates
title_short Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates
title_sort control of igfbp-2 expression by steroids and peptide hormones in vertebrates
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985015/
https://www.ncbi.nlm.nih.gov/pubmed/24778626
http://dx.doi.org/10.3389/fendo.2014.00043
work_keys_str_mv AT hoeflichandreas controlofigfbp2expressionbysteroidsandpeptidehormonesinvertebrates
AT wirthgenelisa controlofigfbp2expressionbysteroidsandpeptidehormonesinvertebrates
AT davidrobert controlofigfbp2expressionbysteroidsandpeptidehormonesinvertebrates
AT classencarlfriedrich controlofigfbp2expressionbysteroidsandpeptidehormonesinvertebrates
AT spitschakmarion controlofigfbp2expressionbysteroidsandpeptidehormonesinvertebrates
AT brenmoehljulia controlofigfbp2expressionbysteroidsandpeptidehormonesinvertebrates

Ejemplares similares