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Resting state functional connectivity in early blind humans

Task-based neuroimaging studies in early blind humans (EB) have demonstrated heightened visual cortex responses to non-visual paradigms. Several prior functional connectivity studies in EB have shown altered connections consistent with these task-based results. But these studies generally did not co...

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Detalles Bibliográficos
Autores principales: Burton, Harold, Snyder, Abraham Z., Raichle, Marcus E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985019/
https://www.ncbi.nlm.nih.gov/pubmed/24778608
http://dx.doi.org/10.3389/fnsys.2014.00051
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author Burton, Harold
Snyder, Abraham Z.
Raichle, Marcus E.
author_facet Burton, Harold
Snyder, Abraham Z.
Raichle, Marcus E.
author_sort Burton, Harold
collection PubMed
description Task-based neuroimaging studies in early blind humans (EB) have demonstrated heightened visual cortex responses to non-visual paradigms. Several prior functional connectivity studies in EB have shown altered connections consistent with these task-based results. But these studies generally did not consider behavioral adaptations to lifelong blindness typically observed in EB. Enhanced cognitive abilities shown in EB include greater serial recall and attention to memory. Here, we address the question of the extent to which brain intrinsic activity in EB reflects such adaptations. We performed a resting-state functional magnetic resonance imaging study contrasting 14 EB with 14 age/gender matched normally sighted controls (NS). A principal finding was markedly greater functional connectivity in EB between visual cortex and regions typically associated with memory and cognitive control of attention. In contrast, correlations between visual cortex and non-deprived sensory cortices were significantly lower in EB. Thus, the available data, including that obtained in prior task-based and resting state fMRI studies, as well as the present results, indicate that visual cortex in EB becomes more heavily incorporated into functional systems instantiating episodic recall and attention to non-visual events. Moreover, EB appear to show a reduction in interactions between visual and non-deprived sensory cortices, possibly reflecting suppression of inter-sensory distracting activity.
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spelling pubmed-39850192014-04-28 Resting state functional connectivity in early blind humans Burton, Harold Snyder, Abraham Z. Raichle, Marcus E. Front Syst Neurosci Neuroscience Task-based neuroimaging studies in early blind humans (EB) have demonstrated heightened visual cortex responses to non-visual paradigms. Several prior functional connectivity studies in EB have shown altered connections consistent with these task-based results. But these studies generally did not consider behavioral adaptations to lifelong blindness typically observed in EB. Enhanced cognitive abilities shown in EB include greater serial recall and attention to memory. Here, we address the question of the extent to which brain intrinsic activity in EB reflects such adaptations. We performed a resting-state functional magnetic resonance imaging study contrasting 14 EB with 14 age/gender matched normally sighted controls (NS). A principal finding was markedly greater functional connectivity in EB between visual cortex and regions typically associated with memory and cognitive control of attention. In contrast, correlations between visual cortex and non-deprived sensory cortices were significantly lower in EB. Thus, the available data, including that obtained in prior task-based and resting state fMRI studies, as well as the present results, indicate that visual cortex in EB becomes more heavily incorporated into functional systems instantiating episodic recall and attention to non-visual events. Moreover, EB appear to show a reduction in interactions between visual and non-deprived sensory cortices, possibly reflecting suppression of inter-sensory distracting activity. Frontiers Media S.A. 2014-04-07 /pmc/articles/PMC3985019/ /pubmed/24778608 http://dx.doi.org/10.3389/fnsys.2014.00051 Text en Copyright © 2014 Burton, Snyder and Raichle. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Burton, Harold
Snyder, Abraham Z.
Raichle, Marcus E.
Resting state functional connectivity in early blind humans
title Resting state functional connectivity in early blind humans
title_full Resting state functional connectivity in early blind humans
title_fullStr Resting state functional connectivity in early blind humans
title_full_unstemmed Resting state functional connectivity in early blind humans
title_short Resting state functional connectivity in early blind humans
title_sort resting state functional connectivity in early blind humans
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985019/
https://www.ncbi.nlm.nih.gov/pubmed/24778608
http://dx.doi.org/10.3389/fnsys.2014.00051
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