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Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia

The aim of this study was to investigate the frequency and mutation status of the immunoglobulin heavy variable chain (IGHV) in a cohort of 224 patients from northwest and central region of Spain diagnosed with chronic lymphocytic leukemia (CLL), and to correlate it with cytogenetic abnormalities, o...

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Autores principales: González-Gascón y Marín, I., Hernández, J. A., Martín, A., Alcoceba, M., Sarasquete, M. E., Rodríguez-Vicente, A., Heras, C., de las Heras, N., Fisac, R., García de Coca, A., de la Fuente, I., Hernández-Sánchez, M., Recio, I., Galende, J., Martín-Núñez, G., Alonso, J. M., Hernández-Rivas, J. M., González, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985179/
https://www.ncbi.nlm.nih.gov/pubmed/24790994
http://dx.doi.org/10.1155/2014/257517
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author González-Gascón y Marín, I.
Hernández, J. A.
Martín, A.
Alcoceba, M.
Sarasquete, M. E.
Rodríguez-Vicente, A.
Heras, C.
de las Heras, N.
Fisac, R.
García de Coca, A.
de la Fuente, I.
Hernández-Sánchez, M.
Recio, I.
Galende, J.
Martín-Núñez, G.
Alonso, J. M.
Hernández-Rivas, J. M.
González, M.
author_facet González-Gascón y Marín, I.
Hernández, J. A.
Martín, A.
Alcoceba, M.
Sarasquete, M. E.
Rodríguez-Vicente, A.
Heras, C.
de las Heras, N.
Fisac, R.
García de Coca, A.
de la Fuente, I.
Hernández-Sánchez, M.
Recio, I.
Galende, J.
Martín-Núñez, G.
Alonso, J. M.
Hernández-Rivas, J. M.
González, M.
author_sort González-Gascón y Marín, I.
collection PubMed
description The aim of this study was to investigate the frequency and mutation status of the immunoglobulin heavy variable chain (IGHV) in a cohort of 224 patients from northwest and central region of Spain diagnosed with chronic lymphocytic leukemia (CLL), and to correlate it with cytogenetic abnormalities, overall survival (OS) and time to first treatment (TTFT). 125 patients had mutated IGHV, while 99 had unmutated IGHV. The most frequently used IGHV family was IGHV3, followed by IGHV1 and IGHV4. The regions IGHV3-30, IGHV1-69, IGHV3-23, and IGHV4-34 were the most commonly used. Only 3.1% of the patients belonged to the subfamily IGHV3-21 and we failed to demonstrate a worse clinical outcome in this subgroup. The IGHV4 family appeared more frequently with mutated pattern, similar to IGHV3-23 and IGHV3-74. By contrast, IGHV1-69 was expressed at a higher frequency in unmutated CLL patients. All the cases from IGHV3-11 and almost all from IGHV5-51 subfamily belonged to the group of unmutated CLL.
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spelling pubmed-39851792014-04-30 Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia González-Gascón y Marín, I. Hernández, J. A. Martín, A. Alcoceba, M. Sarasquete, M. E. Rodríguez-Vicente, A. Heras, C. de las Heras, N. Fisac, R. García de Coca, A. de la Fuente, I. Hernández-Sánchez, M. Recio, I. Galende, J. Martín-Núñez, G. Alonso, J. M. Hernández-Rivas, J. M. González, M. Biomed Res Int Research Article The aim of this study was to investigate the frequency and mutation status of the immunoglobulin heavy variable chain (IGHV) in a cohort of 224 patients from northwest and central region of Spain diagnosed with chronic lymphocytic leukemia (CLL), and to correlate it with cytogenetic abnormalities, overall survival (OS) and time to first treatment (TTFT). 125 patients had mutated IGHV, while 99 had unmutated IGHV. The most frequently used IGHV family was IGHV3, followed by IGHV1 and IGHV4. The regions IGHV3-30, IGHV1-69, IGHV3-23, and IGHV4-34 were the most commonly used. Only 3.1% of the patients belonged to the subfamily IGHV3-21 and we failed to demonstrate a worse clinical outcome in this subgroup. The IGHV4 family appeared more frequently with mutated pattern, similar to IGHV3-23 and IGHV3-74. By contrast, IGHV1-69 was expressed at a higher frequency in unmutated CLL patients. All the cases from IGHV3-11 and almost all from IGHV5-51 subfamily belonged to the group of unmutated CLL. Hindawi Publishing Corporation 2014 2014-03-30 /pmc/articles/PMC3985179/ /pubmed/24790994 http://dx.doi.org/10.1155/2014/257517 Text en Copyright © 2014 I. González-Gascón y Marín et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
González-Gascón y Marín, I.
Hernández, J. A.
Martín, A.
Alcoceba, M.
Sarasquete, M. E.
Rodríguez-Vicente, A.
Heras, C.
de las Heras, N.
Fisac, R.
García de Coca, A.
de la Fuente, I.
Hernández-Sánchez, M.
Recio, I.
Galende, J.
Martín-Núñez, G.
Alonso, J. M.
Hernández-Rivas, J. M.
González, M.
Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia
title Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia
title_full Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia
title_fullStr Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia
title_full_unstemmed Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia
title_short Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia
title_sort mutation status and immunoglobulin gene rearrangements in patients from northwest and central region of spain with chronic lymphocytic leukemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985179/
https://www.ncbi.nlm.nih.gov/pubmed/24790994
http://dx.doi.org/10.1155/2014/257517
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