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A novel membrane fusion protein family in Flaviviridae?

Enveloped viruses must fuse their lipid membrane to a cellular membrane to deliver their genome into the cytoplasm for replication. Viral envelope proteins catalyze this critical membrane fusion event. They fall into three distinct structural classes. In 2013, envelope proteins from a pestivirus and...

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Detalles Bibliográficos
Autores principales: Li, Yue, Modis, Yorgo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985287/
https://www.ncbi.nlm.nih.gov/pubmed/24569295
http://dx.doi.org/10.1016/j.tim.2014.01.008
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author Li, Yue
Modis, Yorgo
author_facet Li, Yue
Modis, Yorgo
author_sort Li, Yue
collection PubMed
description Enveloped viruses must fuse their lipid membrane to a cellular membrane to deliver their genome into the cytoplasm for replication. Viral envelope proteins catalyze this critical membrane fusion event. They fall into three distinct structural classes. In 2013, envelope proteins from a pestivirus and hepatitis C virus were found to have two distinct novel folds. This was unexpected because these viruses are in the same family as flaviviruses, which have class II fusion proteins. We propose that the membrane fusion machinery of the closely related pestiviruses and hepatitis C virus defines a new structural class. This and other recently identified structural relationships between viral fusion proteins shift the paradigm for how these proteins evolved.
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spelling pubmed-39852872015-04-01 A novel membrane fusion protein family in Flaviviridae? Li, Yue Modis, Yorgo Trends Microbiol Article Enveloped viruses must fuse their lipid membrane to a cellular membrane to deliver their genome into the cytoplasm for replication. Viral envelope proteins catalyze this critical membrane fusion event. They fall into three distinct structural classes. In 2013, envelope proteins from a pestivirus and hepatitis C virus were found to have two distinct novel folds. This was unexpected because these viruses are in the same family as flaviviruses, which have class II fusion proteins. We propose that the membrane fusion machinery of the closely related pestiviruses and hepatitis C virus defines a new structural class. This and other recently identified structural relationships between viral fusion proteins shift the paradigm for how these proteins evolved. Elsevier Ltd. 2014-04 2014-02-23 /pmc/articles/PMC3985287/ /pubmed/24569295 http://dx.doi.org/10.1016/j.tim.2014.01.008 Text en Copyright © 2014 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Yue
Modis, Yorgo
A novel membrane fusion protein family in Flaviviridae?
title A novel membrane fusion protein family in Flaviviridae?
title_full A novel membrane fusion protein family in Flaviviridae?
title_fullStr A novel membrane fusion protein family in Flaviviridae?
title_full_unstemmed A novel membrane fusion protein family in Flaviviridae?
title_short A novel membrane fusion protein family in Flaviviridae?
title_sort novel membrane fusion protein family in flaviviridae?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985287/
https://www.ncbi.nlm.nih.gov/pubmed/24569295
http://dx.doi.org/10.1016/j.tim.2014.01.008
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