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Adipokines as Potential Biomarkers in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease characterized by severe joint injury. Recently, research has been focusing on the possible identification of predictor markers of disease onset and/or progression, of joint damage, and of therapeutic response. Recent fin...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985296/ https://www.ncbi.nlm.nih.gov/pubmed/24799765 http://dx.doi.org/10.1155/2014/425068 |
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author | Del Prete, Annalisa Salvi, Valentina Sozzani, Silvano |
author_facet | Del Prete, Annalisa Salvi, Valentina Sozzani, Silvano |
author_sort | Del Prete, Annalisa |
collection | PubMed |
description | Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease characterized by severe joint injury. Recently, research has been focusing on the possible identification of predictor markers of disease onset and/or progression, of joint damage, and of therapeutic response. Recent findings have uncovered the role of white adipose tissue as a pleiotropic organ not only specialized in endocrine functions but also able to control multiple physiopathological processes, including inflammation. Adipokines are a family of soluble mediators secreted by white adipose tissue endowed with a wide spectrum of actions. This review will focus on the recent advances on the role of the adipokine network in the pathogenesis of RA. A particular attention will be devoted to the action of these proteins on RA effector cells, and on the possibility to use circulating levels of adipokines as potential biomarkers of disease activity and therapeutic response. |
format | Online Article Text |
id | pubmed-3985296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39852962014-05-05 Adipokines as Potential Biomarkers in Rheumatoid Arthritis Del Prete, Annalisa Salvi, Valentina Sozzani, Silvano Mediators Inflamm Review Article Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease characterized by severe joint injury. Recently, research has been focusing on the possible identification of predictor markers of disease onset and/or progression, of joint damage, and of therapeutic response. Recent findings have uncovered the role of white adipose tissue as a pleiotropic organ not only specialized in endocrine functions but also able to control multiple physiopathological processes, including inflammation. Adipokines are a family of soluble mediators secreted by white adipose tissue endowed with a wide spectrum of actions. This review will focus on the recent advances on the role of the adipokine network in the pathogenesis of RA. A particular attention will be devoted to the action of these proteins on RA effector cells, and on the possibility to use circulating levels of adipokines as potential biomarkers of disease activity and therapeutic response. Hindawi Publishing Corporation 2014 2014-03-30 /pmc/articles/PMC3985296/ /pubmed/24799765 http://dx.doi.org/10.1155/2014/425068 Text en Copyright © 2014 Annalisa Del Prete et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Del Prete, Annalisa Salvi, Valentina Sozzani, Silvano Adipokines as Potential Biomarkers in Rheumatoid Arthritis |
title | Adipokines as Potential Biomarkers in Rheumatoid Arthritis |
title_full | Adipokines as Potential Biomarkers in Rheumatoid Arthritis |
title_fullStr | Adipokines as Potential Biomarkers in Rheumatoid Arthritis |
title_full_unstemmed | Adipokines as Potential Biomarkers in Rheumatoid Arthritis |
title_short | Adipokines as Potential Biomarkers in Rheumatoid Arthritis |
title_sort | adipokines as potential biomarkers in rheumatoid arthritis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985296/ https://www.ncbi.nlm.nih.gov/pubmed/24799765 http://dx.doi.org/10.1155/2014/425068 |
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