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Fall in Vitamin D Levels during Hospitalization in Children

Plasma levels of 25-hydroxyvitamin D [25(OH)D] were measured by competitive Electrochemiluminescence Immunoassay (ECLIA) in 92 children (67 boys, 25 girls) aged 3 months to 12 years at admission to hospital (timepoint 1, T1) and at discharge (timepoint 2, T2). There was a significant fall in the mea...

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Autores principales: Dayal, Devi, Kumar, Suresh, Sachdeva, Naresh, Kumar, Rakesh, Singh, Meenu, Singhi, Sunit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985317/
https://www.ncbi.nlm.nih.gov/pubmed/24860607
http://dx.doi.org/10.1155/2014/291856
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author Dayal, Devi
Kumar, Suresh
Sachdeva, Naresh
Kumar, Rakesh
Singh, Meenu
Singhi, Sunit
author_facet Dayal, Devi
Kumar, Suresh
Sachdeva, Naresh
Kumar, Rakesh
Singh, Meenu
Singhi, Sunit
author_sort Dayal, Devi
collection PubMed
description Plasma levels of 25-hydroxyvitamin D [25(OH)D] were measured by competitive Electrochemiluminescence Immunoassay (ECLIA) in 92 children (67 boys, 25 girls) aged 3 months to 12 years at admission to hospital (timepoint 1, T1) and at discharge (timepoint 2, T2). There was a significant fall in the mean 25(OH)D from T1 (71.87 ± 27.25 nmol/L) to T2 (49.03 ± 22.25 nmol/L) (mean change = 22.84 nmol/L, P value = 0.0004). Proportion of patients having VDD (levels <50 nmol/L) at admission (25%, 23/92) increased significantly at the time of discharge (51.09%, 47/92) (P = 0.0004). There was a trend towards longer duration of hospital stay, requirement of ventilation and inotropes, development of healthcare-associated infection, and mortality in vitamin D deficient as compared to nondeficient patients though the difference was statistically insignificant. In conclusion, vitamin D levels fall significantly and should be monitored during hospital stay in children. Large clinical studies are needed to prospectively evaluate the effect of vitamin D supplementation in vitamin D deficient hospitalized children on various disease outcome parameters.
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spelling pubmed-39853172014-05-25 Fall in Vitamin D Levels during Hospitalization in Children Dayal, Devi Kumar, Suresh Sachdeva, Naresh Kumar, Rakesh Singh, Meenu Singhi, Sunit Int J Pediatr Research Article Plasma levels of 25-hydroxyvitamin D [25(OH)D] were measured by competitive Electrochemiluminescence Immunoassay (ECLIA) in 92 children (67 boys, 25 girls) aged 3 months to 12 years at admission to hospital (timepoint 1, T1) and at discharge (timepoint 2, T2). There was a significant fall in the mean 25(OH)D from T1 (71.87 ± 27.25 nmol/L) to T2 (49.03 ± 22.25 nmol/L) (mean change = 22.84 nmol/L, P value = 0.0004). Proportion of patients having VDD (levels <50 nmol/L) at admission (25%, 23/92) increased significantly at the time of discharge (51.09%, 47/92) (P = 0.0004). There was a trend towards longer duration of hospital stay, requirement of ventilation and inotropes, development of healthcare-associated infection, and mortality in vitamin D deficient as compared to nondeficient patients though the difference was statistically insignificant. In conclusion, vitamin D levels fall significantly and should be monitored during hospital stay in children. Large clinical studies are needed to prospectively evaluate the effect of vitamin D supplementation in vitamin D deficient hospitalized children on various disease outcome parameters. Hindawi Publishing Corporation 2014 2014-03-30 /pmc/articles/PMC3985317/ /pubmed/24860607 http://dx.doi.org/10.1155/2014/291856 Text en Copyright © 2014 Devi Dayal et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dayal, Devi
Kumar, Suresh
Sachdeva, Naresh
Kumar, Rakesh
Singh, Meenu
Singhi, Sunit
Fall in Vitamin D Levels during Hospitalization in Children
title Fall in Vitamin D Levels during Hospitalization in Children
title_full Fall in Vitamin D Levels during Hospitalization in Children
title_fullStr Fall in Vitamin D Levels during Hospitalization in Children
title_full_unstemmed Fall in Vitamin D Levels during Hospitalization in Children
title_short Fall in Vitamin D Levels during Hospitalization in Children
title_sort fall in vitamin d levels during hospitalization in children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985317/
https://www.ncbi.nlm.nih.gov/pubmed/24860607
http://dx.doi.org/10.1155/2014/291856
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