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Fall in Vitamin D Levels during Hospitalization in Children
Plasma levels of 25-hydroxyvitamin D [25(OH)D] were measured by competitive Electrochemiluminescence Immunoassay (ECLIA) in 92 children (67 boys, 25 girls) aged 3 months to 12 years at admission to hospital (timepoint 1, T1) and at discharge (timepoint 2, T2). There was a significant fall in the mea...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985317/ https://www.ncbi.nlm.nih.gov/pubmed/24860607 http://dx.doi.org/10.1155/2014/291856 |
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author | Dayal, Devi Kumar, Suresh Sachdeva, Naresh Kumar, Rakesh Singh, Meenu Singhi, Sunit |
author_facet | Dayal, Devi Kumar, Suresh Sachdeva, Naresh Kumar, Rakesh Singh, Meenu Singhi, Sunit |
author_sort | Dayal, Devi |
collection | PubMed |
description | Plasma levels of 25-hydroxyvitamin D [25(OH)D] were measured by competitive Electrochemiluminescence Immunoassay (ECLIA) in 92 children (67 boys, 25 girls) aged 3 months to 12 years at admission to hospital (timepoint 1, T1) and at discharge (timepoint 2, T2). There was a significant fall in the mean 25(OH)D from T1 (71.87 ± 27.25 nmol/L) to T2 (49.03 ± 22.25 nmol/L) (mean change = 22.84 nmol/L, P value = 0.0004). Proportion of patients having VDD (levels <50 nmol/L) at admission (25%, 23/92) increased significantly at the time of discharge (51.09%, 47/92) (P = 0.0004). There was a trend towards longer duration of hospital stay, requirement of ventilation and inotropes, development of healthcare-associated infection, and mortality in vitamin D deficient as compared to nondeficient patients though the difference was statistically insignificant. In conclusion, vitamin D levels fall significantly and should be monitored during hospital stay in children. Large clinical studies are needed to prospectively evaluate the effect of vitamin D supplementation in vitamin D deficient hospitalized children on various disease outcome parameters. |
format | Online Article Text |
id | pubmed-3985317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39853172014-05-25 Fall in Vitamin D Levels during Hospitalization in Children Dayal, Devi Kumar, Suresh Sachdeva, Naresh Kumar, Rakesh Singh, Meenu Singhi, Sunit Int J Pediatr Research Article Plasma levels of 25-hydroxyvitamin D [25(OH)D] were measured by competitive Electrochemiluminescence Immunoassay (ECLIA) in 92 children (67 boys, 25 girls) aged 3 months to 12 years at admission to hospital (timepoint 1, T1) and at discharge (timepoint 2, T2). There was a significant fall in the mean 25(OH)D from T1 (71.87 ± 27.25 nmol/L) to T2 (49.03 ± 22.25 nmol/L) (mean change = 22.84 nmol/L, P value = 0.0004). Proportion of patients having VDD (levels <50 nmol/L) at admission (25%, 23/92) increased significantly at the time of discharge (51.09%, 47/92) (P = 0.0004). There was a trend towards longer duration of hospital stay, requirement of ventilation and inotropes, development of healthcare-associated infection, and mortality in vitamin D deficient as compared to nondeficient patients though the difference was statistically insignificant. In conclusion, vitamin D levels fall significantly and should be monitored during hospital stay in children. Large clinical studies are needed to prospectively evaluate the effect of vitamin D supplementation in vitamin D deficient hospitalized children on various disease outcome parameters. Hindawi Publishing Corporation 2014 2014-03-30 /pmc/articles/PMC3985317/ /pubmed/24860607 http://dx.doi.org/10.1155/2014/291856 Text en Copyright © 2014 Devi Dayal et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dayal, Devi Kumar, Suresh Sachdeva, Naresh Kumar, Rakesh Singh, Meenu Singhi, Sunit Fall in Vitamin D Levels during Hospitalization in Children |
title | Fall in Vitamin D Levels during Hospitalization in Children |
title_full | Fall in Vitamin D Levels during Hospitalization in Children |
title_fullStr | Fall in Vitamin D Levels during Hospitalization in Children |
title_full_unstemmed | Fall in Vitamin D Levels during Hospitalization in Children |
title_short | Fall in Vitamin D Levels during Hospitalization in Children |
title_sort | fall in vitamin d levels during hospitalization in children |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985317/ https://www.ncbi.nlm.nih.gov/pubmed/24860607 http://dx.doi.org/10.1155/2014/291856 |
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