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Cancer Risks for Relatives of Children with Cancer

We determined the extent and distribution of cancers in relatives of 379 children newly diagnosed with cancer. Family history was collected from 1,337 first-degree and 3,399 second-degree relatives and incidence compared with national age- and gender-specific rates. Overall, 14 children (3.7%) had a...

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Autores principales: Heath, John A., Smibert, Elizabeth, Algar, Elizabeth M., Dite, Gillian S., Hopper, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985329/
https://www.ncbi.nlm.nih.gov/pubmed/24799902
http://dx.doi.org/10.1155/2014/806076
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author Heath, John A.
Smibert, Elizabeth
Algar, Elizabeth M.
Dite, Gillian S.
Hopper, John L.
author_facet Heath, John A.
Smibert, Elizabeth
Algar, Elizabeth M.
Dite, Gillian S.
Hopper, John L.
author_sort Heath, John A.
collection PubMed
description We determined the extent and distribution of cancers in relatives of 379 children newly diagnosed with cancer. Family history was collected from 1,337 first-degree and 3,399 second-degree relatives and incidence compared with national age- and gender-specific rates. Overall, 14 children (3.7%) had a relative with a history of childhood cancer and 26 children (6.9%) had a first-degree relative with a history of cancer, with only one of these having an identifiable familial cancer syndrome. There was a higher than expected incidence of childhood cancer among first-degree relatives (parents and siblings) (standardized incidence ratio (SIR) 1.43; 95% CI 0.54–5.08). There was also a higher than expected incidence of adult cancers among first-degree relatives (SIR 1.45; 95% CI 0.93–2.21), particularly in females (SIR 1.82; 95% CI 1.26–3.39). The increased family cancer history in first-degree females was largely attributable to an effect in mothers (SIR 1.78; 95% CI 1.27–3.33). The gender-specific association was reflected in higher than expected incidence rates of breast cancer in both mothers (SIR 1.92; 95% CI 0.72–6.83) and aunts (SIR 1.64; 95% CI 0.98–2.94). These findings support the hypothesis that previously undetected familial cancer syndromes contribute to childhood cancer.
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spelling pubmed-39853292014-05-05 Cancer Risks for Relatives of Children with Cancer Heath, John A. Smibert, Elizabeth Algar, Elizabeth M. Dite, Gillian S. Hopper, John L. J Cancer Epidemiol Research Article We determined the extent and distribution of cancers in relatives of 379 children newly diagnosed with cancer. Family history was collected from 1,337 first-degree and 3,399 second-degree relatives and incidence compared with national age- and gender-specific rates. Overall, 14 children (3.7%) had a relative with a history of childhood cancer and 26 children (6.9%) had a first-degree relative with a history of cancer, with only one of these having an identifiable familial cancer syndrome. There was a higher than expected incidence of childhood cancer among first-degree relatives (parents and siblings) (standardized incidence ratio (SIR) 1.43; 95% CI 0.54–5.08). There was also a higher than expected incidence of adult cancers among first-degree relatives (SIR 1.45; 95% CI 0.93–2.21), particularly in females (SIR 1.82; 95% CI 1.26–3.39). The increased family cancer history in first-degree females was largely attributable to an effect in mothers (SIR 1.78; 95% CI 1.27–3.33). The gender-specific association was reflected in higher than expected incidence rates of breast cancer in both mothers (SIR 1.92; 95% CI 0.72–6.83) and aunts (SIR 1.64; 95% CI 0.98–2.94). These findings support the hypothesis that previously undetected familial cancer syndromes contribute to childhood cancer. Hindawi Publishing Corporation 2014 2014-03-27 /pmc/articles/PMC3985329/ /pubmed/24799902 http://dx.doi.org/10.1155/2014/806076 Text en Copyright © 2014 John A. Heath et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Heath, John A.
Smibert, Elizabeth
Algar, Elizabeth M.
Dite, Gillian S.
Hopper, John L.
Cancer Risks for Relatives of Children with Cancer
title Cancer Risks for Relatives of Children with Cancer
title_full Cancer Risks for Relatives of Children with Cancer
title_fullStr Cancer Risks for Relatives of Children with Cancer
title_full_unstemmed Cancer Risks for Relatives of Children with Cancer
title_short Cancer Risks for Relatives of Children with Cancer
title_sort cancer risks for relatives of children with cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985329/
https://www.ncbi.nlm.nih.gov/pubmed/24799902
http://dx.doi.org/10.1155/2014/806076
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