Cargando…
Cancer Risks for Relatives of Children with Cancer
We determined the extent and distribution of cancers in relatives of 379 children newly diagnosed with cancer. Family history was collected from 1,337 first-degree and 3,399 second-degree relatives and incidence compared with national age- and gender-specific rates. Overall, 14 children (3.7%) had a...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985329/ https://www.ncbi.nlm.nih.gov/pubmed/24799902 http://dx.doi.org/10.1155/2014/806076 |
_version_ | 1782311559069958144 |
---|---|
author | Heath, John A. Smibert, Elizabeth Algar, Elizabeth M. Dite, Gillian S. Hopper, John L. |
author_facet | Heath, John A. Smibert, Elizabeth Algar, Elizabeth M. Dite, Gillian S. Hopper, John L. |
author_sort | Heath, John A. |
collection | PubMed |
description | We determined the extent and distribution of cancers in relatives of 379 children newly diagnosed with cancer. Family history was collected from 1,337 first-degree and 3,399 second-degree relatives and incidence compared with national age- and gender-specific rates. Overall, 14 children (3.7%) had a relative with a history of childhood cancer and 26 children (6.9%) had a first-degree relative with a history of cancer, with only one of these having an identifiable familial cancer syndrome. There was a higher than expected incidence of childhood cancer among first-degree relatives (parents and siblings) (standardized incidence ratio (SIR) 1.43; 95% CI 0.54–5.08). There was also a higher than expected incidence of adult cancers among first-degree relatives (SIR 1.45; 95% CI 0.93–2.21), particularly in females (SIR 1.82; 95% CI 1.26–3.39). The increased family cancer history in first-degree females was largely attributable to an effect in mothers (SIR 1.78; 95% CI 1.27–3.33). The gender-specific association was reflected in higher than expected incidence rates of breast cancer in both mothers (SIR 1.92; 95% CI 0.72–6.83) and aunts (SIR 1.64; 95% CI 0.98–2.94). These findings support the hypothesis that previously undetected familial cancer syndromes contribute to childhood cancer. |
format | Online Article Text |
id | pubmed-3985329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39853292014-05-05 Cancer Risks for Relatives of Children with Cancer Heath, John A. Smibert, Elizabeth Algar, Elizabeth M. Dite, Gillian S. Hopper, John L. J Cancer Epidemiol Research Article We determined the extent and distribution of cancers in relatives of 379 children newly diagnosed with cancer. Family history was collected from 1,337 first-degree and 3,399 second-degree relatives and incidence compared with national age- and gender-specific rates. Overall, 14 children (3.7%) had a relative with a history of childhood cancer and 26 children (6.9%) had a first-degree relative with a history of cancer, with only one of these having an identifiable familial cancer syndrome. There was a higher than expected incidence of childhood cancer among first-degree relatives (parents and siblings) (standardized incidence ratio (SIR) 1.43; 95% CI 0.54–5.08). There was also a higher than expected incidence of adult cancers among first-degree relatives (SIR 1.45; 95% CI 0.93–2.21), particularly in females (SIR 1.82; 95% CI 1.26–3.39). The increased family cancer history in first-degree females was largely attributable to an effect in mothers (SIR 1.78; 95% CI 1.27–3.33). The gender-specific association was reflected in higher than expected incidence rates of breast cancer in both mothers (SIR 1.92; 95% CI 0.72–6.83) and aunts (SIR 1.64; 95% CI 0.98–2.94). These findings support the hypothesis that previously undetected familial cancer syndromes contribute to childhood cancer. Hindawi Publishing Corporation 2014 2014-03-27 /pmc/articles/PMC3985329/ /pubmed/24799902 http://dx.doi.org/10.1155/2014/806076 Text en Copyright © 2014 John A. Heath et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Heath, John A. Smibert, Elizabeth Algar, Elizabeth M. Dite, Gillian S. Hopper, John L. Cancer Risks for Relatives of Children with Cancer |
title | Cancer Risks for Relatives of Children with Cancer |
title_full | Cancer Risks for Relatives of Children with Cancer |
title_fullStr | Cancer Risks for Relatives of Children with Cancer |
title_full_unstemmed | Cancer Risks for Relatives of Children with Cancer |
title_short | Cancer Risks for Relatives of Children with Cancer |
title_sort | cancer risks for relatives of children with cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985329/ https://www.ncbi.nlm.nih.gov/pubmed/24799902 http://dx.doi.org/10.1155/2014/806076 |
work_keys_str_mv | AT heathjohna cancerrisksforrelativesofchildrenwithcancer AT smibertelizabeth cancerrisksforrelativesofchildrenwithcancer AT algarelizabethm cancerrisksforrelativesofchildrenwithcancer AT ditegillians cancerrisksforrelativesofchildrenwithcancer AT hopperjohnl cancerrisksforrelativesofchildrenwithcancer |