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A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain
[Image: see text] Optimization of drug efficacy in the brain requires understanding of the local exposure to unbound drug at the site of action. This relies on measurements of the unbound drug fraction (f(u,brain)), which currently requires access to brain tissue. Here, we present a novel methodolog...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985417/ https://www.ncbi.nlm.nih.gov/pubmed/24601604 http://dx.doi.org/10.1021/jm401963n |