Cargando…

Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides

[Image: see text] A-kinase anchoring proteins (AKAPs) play an important role in the spatial and temporal regulation of protein kinase A (PKA) by scaffolding critical intracellular signaling complexes. Here we report the design of conformationally constrained peptides that disrupt interactions betwee...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yuxiao, Ho, Tienhuei G., Bertinetti, Daniela, Neddermann, Matthias, Franz, Eugen, Mo, Gary C. H., Schendowich, Lewis P., Sukhu, Avinash, Spelts, Raybun C., Zhang, Jin, Herberg, Friedrich W., Kennedy, Eileen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985448/ https://www.ncbi.nlm.nih.gov/pubmed/24422448 http://dx.doi.org/10.1021/cb400900r

Ejemplares similares

Correction to Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides
por: Wang, Yuxiao, et al.
Publicado: (2014)

The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism
por: Flaherty, Briana R., et al.
Publicado: (2015)

Chemical tools selectively target components of the PKA system
por: Bertinetti, Daniela, et al.
Publicado: (2009)

Transforming PKA into PKG – a structure-function approach to understand cyclic nucleotide selectivity
por: Lorenz, Robin, et al.
Publicado: (2013)

PKA Compartmentalization via AKAP220 and AKAP12 Contributes to Endothelial Barrier Regulation
por: Radeva, Mariya Y., et al.
Publicado: (2014)

Dissociation between AKAP3 and PKA(RII) Promotes AKAP3 Degradation in Sperm Capacitation
por: Hillman, Pnina, et al.
Publicado: (2013)

Mechanism of Neuroprotective Mitochondrial Remodeling by PKA/AKAP1
por: Merrill, Ronald A., et al.
Publicado: (2011)

PKA, PKC, and AKAP localization in and around the neuromuscular junction
por: Perkins, Guy A, et al.
Publicado: (2001)

Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP–PKA Interactions**
por: Schäfer, Gesa, et al.
Publicado: (2013)

Molecular Basis for Ser/Thr Specificity in PKA Signaling
por: Knape, Matthias J., et al.
Publicado: (2020)

Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes
por: Christian, Frank, et al.
Publicado: (2011)

AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency
por: Gold, Matthew G, et al.
Publicado: (2012)

Differential PKA activation and AKAP association determines cell fate in cancer cells
por: Hedrick, Erik D, et al.
Publicado: (2013)

Hydrocarbon Stapled Antimicrobial Peptides
por: Migoń, Dorian, et al.
Publicado: (2018)

A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A
por: Manschwetus, Jascha T., et al.
Publicado: (2019)

AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repair
por: Jarrett, Stuart G., et al.
Publicado: (2016)

Targeting FRET-Based Reporters for cAMP and PKA Activity Using AKAP79
por: Musheshe, Nshunge, et al.
Publicado: (2018)

Crystal structures of the carboxyl cGMP binding domain of plasmodium falciparum cGMP-dependent protein kinase reveals a novel salt bridge crucial for activation
por: Kim, Jeong Joo, et al.
Publicado: (2013)

The role of a parasite-specific D-site in activation of Plasmodium falciparum cGMP-dependent protein kinase
por: Franz, Eugen, et al.
Publicado: (2015)

Molecular evolution of a-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalization
por: Johnson, Keven R, et al.
Publicado: (2012)

Retraction: AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repair
por: Jarrett, Stuart G, et al.
Publicado: (2020)

Phosphoproteomic Analysis Reveals Downstream PKA Effectors of AKAP Cypher/ZASP in the Pathogenesis of Dilated Cardiomyopathy
por: Lv, Jialan, et al.
Publicado: (2021)

Targeted disruption of PKC from AKAP signaling complexes
por: Limaye, Ameya J., et al.
Publicado: (2021)

Regulation of Cardiac PKA Signaling by cAMP and Oxidants
por: Cuello, Friederike, et al.
Publicado: (2021)

Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2
por: Manschwetus, Jascha T., et al.
Publicado: (2020)

Curcumin Protects Neurons from Glutamate-Induced Excitotoxicity by Membrane Anchored AKAP79-PKA Interaction Network
por: Chen, Kui, et al.
Publicado: (2015)

AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus
por: Ando, Fumiaki, et al.
Publicado: (2018)

Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle
por: Baarsma, Hoeke A., et al.
Publicado: (2020)

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress: Miniperspective
por: Walensky, Loren D., et al.
Publicado: (2014)

Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides
por: Lai, Ying, et al.
Publicado: (2022)

Rational design of a PKA-based sensor for cGMP
por: Lorenz, Robin, et al.
Publicado: (2015)

Isoform-specific targeting of PKA to multivesicular bodies
por: Day, Michele E., et al.
Publicado: (2011)

The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA
por: Vetter, Maike M, et al.
Publicado: (2011)

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome
por: Terrin, Anna, et al.
Publicado: (2012)

Compartmentalization Role of A-Kinase Anchoring Proteins (AKAPs) in Mediating Protein Kinase A (PKA) Signaling and Cardiomyocyte Hypertrophy
por: Rababa’h, Abeer, et al.
Publicado: (2014)

The AKAP Cypher/Zasp contributes to β-adrenergic/PKA stimulation of cardiac Ca(V)1.2 calcium channels
por: Yu, Haijie, et al.
Publicado: (2018)

AKAP5 and AKAP12 Form Homo-oligomers
por: Gao, Shujuan, et al.
Publicado: (2011)

Biophysical Determinants for Cellular Uptake of Hydrocarbon-Stapled Peptide Helices
por: Bird, Gregory H., et al.
Publicado: (2016)

Hydrocarbon-Stapled Peptide Based-Nanoparticles for siRNA Delivery
por: Simon, Matthieu, et al.
Publicado: (2020)

Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis
por: Lai, Ying, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_b1litvq154tu2pq2gp9eenlmrp