Structure determination of noncanonical RNA motifs guided by (1)H NMR chemical shifts

Structured non-coding RNAs underline fundamental cellular processes, but determining their 3D structures remains challenging. We demonstrate herein that integrating NMR (1)H chemical shift data with Rosetta de novo modeling can consistently return high-resolution RNA structures. On a benchmark set o...

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Detalles Bibliográficos
Autores principales: Sripakdeevong, Parin, Cevec, Mirko, Chang, Andrew T., Erat, Michèle C., Ziegeler, Melanie, Zhao, Qin, Fox, George E., Gao, Xiaolian, Kennedy, Scott D., Kierzek, Ryszard, Nikonowicz, Edward P., Schwalbe, Harald, Sigel, Roland K. O., Turner, Douglas H., Das, Rhiju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985481/
https://www.ncbi.nlm.nih.gov/pubmed/24584194
http://dx.doi.org/10.1038/nmeth.2876

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