MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters

Mixed-lineage leukemia (MLL) maintains the expression of cellular memory genes during development, while leukemic MLL fusion proteins aberrantly maintain expression of hematopoietic stem cell program genes such as HOXA9 to cause leukemia. However, the molecular mechanism of gene activation is unclea...

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Detalles Bibliográficos
Autores principales: Okuda, Hiroshi, Kawaguchi, Marie, Kanai, Akinori, Matsui, Hirotaka, Kawamura, Takeshi, Inaba, Toshiya, Kitabayashi, Issay, Yokoyama, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985622/
https://www.ncbi.nlm.nih.gov/pubmed/24465000
http://dx.doi.org/10.1093/nar/gkt1394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985622/
https://www.ncbi.nlm.nih.gov/pubmed/24465000
http://dx.doi.org/10.1093/nar/gkt1394

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