Cargando…

MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters

Mixed-lineage leukemia (MLL) maintains the expression of cellular memory genes during development, while leukemic MLL fusion proteins aberrantly maintain expression of hematopoietic stem cell program genes such as HOXA9 to cause leukemia. However, the molecular mechanism of gene activation is unclea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Okuda, Hiroshi, Kawaguchi, Marie, Kanai, Akinori, Matsui, Hirotaka, Kawamura, Takeshi, Inaba, Toshiya, Kitabayashi, Issay, Yokoyama, Akihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985622/ https://www.ncbi.nlm.nih.gov/pubmed/24465000 http://dx.doi.org/10.1093/nar/gkt1394

Ejemplares similares

The impact of intragenic CpG content on gene expression
por: Bauer, Asli Petra, et al.
Publicado: (2010)

Cytosine methylation at CpCpG sites triggers accumulation of non-CpG methylation in gene bodies
por: Zabet, Nicolae Radu, et al.
Publicado: (2017)

No evidence of extensive non-CpG methylation in mtDNA
por: Guitton, Romain, et al.
Publicado: (2022)

CpG domains downstream of TSSs promote high levels of gene expression
por: Krinner, Simone, et al.
Publicado: (2014)

Implications of CpG islands on chromosomal architectures and modes of global gene regulation
por: Beck, Samuel, et al.
Publicado: (2018)

DNA methylation in human epigenomes depends on local topology of CpG sites
por: Lövkvist, Cecilia, et al.
Publicado: (2016)

Human mitochondrial DNA is extensively methylated in a non-CpG context
por: Patil, Vibha, et al.
Publicado: (2019)

The homeodomain of Oct4 is a dimeric binder of methylated CpG elements
por: Tan, Daisylyn Senna, et al.
Publicado: (2023)

Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved
por: Long, Hannah K., et al.
Publicado: (2016)

Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development
por: Ichiyanagi, Tomoko, et al.
Publicado: (2013)

Collaboration between CpG sites is needed for stable somatic inheritance of DNA methylation states
por: Haerter, Jan O., et al.
Publicado: (2014)

Effects of non-CpG site methylation on DNA thermal stability: a fluorescence study
por: Nardo, Luca, et al.
Publicado: (2015)

GC skew is a conserved property of unmethylated CpG island promoters across vertebrates
por: Hartono, Stella R., et al.
Publicado: (2015)

Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting
por: Patiño-Parrado, Iris, et al.
Publicado: (2017)

DNA strand asymmetry generated by CpG hemimethylation has opposing effects on CTCF binding
por: Thomas, Stacey L, et al.
Publicado: (2023)

CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity
por: Evison, Benny J., et al.
Publicado: (2009)

A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands
por: Kong, Lingchun, et al.
Publicado: (2016)

Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters
por: Ni, Weiya, et al.
Publicado: (2020)

Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing
por: Amante, Samuele M, et al.
Publicado: (2020)

Single-molecule mitochondrial DNA sequencing shows no evidence of CpG methylation in human cells and tissues
por: Bicci, Iacopo, et al.
Publicado: (2021)

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis
por: Lai, Binbin, et al.
Publicado: (2017)

Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites
por: Kozlenkov, Alexey, et al.
Publicado: (2014)

Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites
por: Lee, Seung-Tae, et al.
Publicado: (2016)

Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences
por: Günther, Katharina, et al.
Publicado: (2013)

Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts
por: Zhang, Donghong, et al.
Publicado: (2017)

Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B mono-ubiquitination
por: Lee, Bum-Kyu, et al.
Publicado: (2017)

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity
por: Turberfield, Anne H, et al.
Publicado: (2019)

Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island
por: Zhang, Yan, et al.
Publicado: (2012)

Comparative analysis using K-mer and K-flank patterns provides evidence for CpG island sequence evolution in mammalian genomes
por: Chae, Heejoon, et al.
Publicado: (2013)

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
por: Weber, Lisa Marie, et al.
Publicado: (2022)

Requirement of CRTC1 coactivator for hepatitis B virus transcription
por: Tang, Hei-Man Vincent, et al.
Publicado: (2014)

H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development
por: Jang, Younghoon, et al.
Publicado: (2019)

Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter
por: Kitsera, Nataliya, et al.
Publicado: (2017)

Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner
por: Zhang, Peng, et al.
Publicado: (2017)

Potential role of DNA methylation as a facilitator of target search processes for transcription factors through interplay with methyl-CpG-binding proteins
por: Kemme, Catherine A., et al.
Publicado: (2017)

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation
por: Marinello, Jessica, et al.
Publicado: (2013)

An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex
por: Desai, Megha A., et al.
Publicado: (2015)

Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells
por: Miotto, Benoit, et al.
Publicado: (2018)

Inactive X chromosome-specific histone H3 modifications and CpG hypomethylation flank a chromatin boundary between an X-inactivated and an escape gene
por: Goto, Yuji, et al.
Publicado: (2009)

The interaction of mycobacterial protein Rv2966c with host chromatin is mediated through non-CpG methylation and histone H3/H4 binding
por: Sharma, Garima, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_jvqcftitf3ielorhjbgnvs2jd7