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DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response

The ataxia telangiectasia mutated and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) axis is the major signaling pathway activated in response to replication stress and is essential for the intra-S checkpoint. ATR phosphorylates and activates a number of molecules to coordinate cell cycle progression...

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Detalles Bibliográficos
Autores principales:	Lin, Yu-Fen, Shih, Hung-Ying, Shang, Zengfu, Matsunaga, Shinji, Chen, Benjamin PC
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985680/ https://www.ncbi.nlm.nih.gov/pubmed/24500207 http://dx.doi.org/10.1093/nar/gku116

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