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Predicting the Impact of Missense Mutations on Protein–Protein Binding Affinity

[Image: see text] The crucial prerequisite for proper biological function is the protein’s ability to establish highly selective interactions with macromolecular partners. A missense mutation that alters the protein binding affinity may cause significant perturbations or complete abolishment of the...

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Detalles Bibliográficos
Autores principales:	Li, Minghui, Petukh, Marharyta, Alexov, Emil, Panchenko, Anna R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985714/ https://www.ncbi.nlm.nih.gov/pubmed/24803870 http://dx.doi.org/10.1021/ct401022c

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