Interfacial Residues Promote an Optimal Alignment of the Catalytic Center in Human Soluble Guanylate Cyclase: Heterodimerization Is Required but Not Sufficient for Activity

[Image: see text] Soluble guanylate cyclase (sGC) plays a central role in the cardiovascular system and is a drug target for the treatment of pulmonary hypertension. While the three-dimensional structure of sGC is unknown, studies suggest that binding of the regulatory domain to the catalytic domain...

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Detalles Bibliográficos
Autores principales: Seeger, Franziska, Quintyn, Royston, Tanimoto, Akiko, Williams, Gareth J., Tainer, John A., Wysocki, Vicki H., Garcin, Elsa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985721/
https://www.ncbi.nlm.nih.gov/pubmed/24669844
http://dx.doi.org/10.1021/bi500129k

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