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Replacing the Axial Ligand Tyrosine 75 or Its Hydrogen Bond Partner Histidine 83 Minimally Affects Hemin Acquisition by the Hemophore HasAp from Pseudomonas aeruginosa

[Image: see text] Hemophores from Pseudomonas aeruginosa (HasAp), Serratia marcescens (HasA(sm)), and Yersinia pestis (HasA(yp)) bind hemin between two loops. One of the loops harbors conserved axial ligand Tyr75 (Y75 loop) in all three structures, whereas the second loop (H32 loop) contains axial l...

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Detalles Bibliográficos
Autores principales:	Kumar, Ritesh, Matsumura, Hirotoshi, Lovell, Scott, Yao, Huili, Rodríguez, Juan C., Battaile, Kevin P., Moënne-Loccoz, Pierre, Rivera, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985777/ https://www.ncbi.nlm.nih.gov/pubmed/24625274 http://dx.doi.org/10.1021/bi500030p

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