Cargando…

How pH Modulates the Reactivity and Selectivity of a Siderophore-Associated Flavin Monooxygenase

[Image: see text] Flavin-containing monooxygenases (FMOs) catalyze the oxygenation of diverse organic molecules using O(2), NADPH, and the flavin adenine dinucleotide (FAD) cofactor. The fungal FMO SidA initiates peptidic siderophore biosynthesis via the highly selective hydroxylation of l-ornithine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frederick, Rosanne E., Ojha, Sunil, Lamb, Audrey, DuBois, Jennifer L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985866/ https://www.ncbi.nlm.nih.gov/pubmed/24490904 http://dx.doi.org/10.1021/bi401256b

Ejemplares similares

Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases
por: Mascotti, Maria Laura, et al.
Publicado: (2016)

Evolution of enzyme functionality in the flavin-containing monooxygenases
por: Bailleul, Gautier, et al.
Publicado: (2023)

The Origin and Evolution of Baeyer—Villiger Monooxygenases (BVMOs): An Ancestral Family of Flavin Monooxygenases
por: Mascotti, Maria Laura, et al.
Publicado: (2015)

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
por: Miao, Ji, et al.
Publicado: (2015)

Flavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism
por: Huang, Shijiao, et al.
Publicado: (2021)

QM/MM Modeling of the Flavin Functionalization in the RutA Monooxygenase
por: Grigorenko, Bella, et al.
Publicado: (2023)

Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis
por: Wang, Qian, et al.
Publicado: (2023)

Two Novel Flavin-Containing Monooxygenases Involved in Biosynthesis of Aliphatic Glucosinolates
por: Kong, Wenwen, et al.
Publicado: (2016)

Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity
por: Crocker, Leander, et al.
Publicado: (2019)

Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates
por: Goris, Marianne, et al.
Publicado: (2020)

Metabolic Regulation of Longevity by One-Carbon Metabolism and Flavin-Containing Monooxygenase
por: Choi, Christopher, et al.
Publicado: (2020)

Properties and Mechanisms of Flavin-Dependent Monooxygenases and Their Applications in Natural Product Synthesis
por: Deng, Yaming, et al.
Publicado: (2022)

Engineered Bacterial Flavin‐Dependent Monooxygenases for the Regiospecific Hydroxylation of Polycyclic Phenols
por: Herrmann, Susann, et al.
Publicado: (2022)

A flavin-monooxygenase catalyzing oxepinone formation and the complete biosynthesis of vibralactone
por: Feng, Ke-Na, et al.
Publicado: (2023)

C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress
por: Hirani, Nisha, et al.
Publicado: (2016)

C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress
por: Hirani, Nisha, et al.
Publicado: (2016)

Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
por: El-Serafi, Ibrahim, et al.
Publicado: (2017)

Oxidative dehalogenation and denitration by a flavin-dependent monooxygenase is controlled by substrate deprotonation
por: Pimviriyakul, Panu, et al.
Publicado: (2018)

FLAVIN-CONTAINING MONOOXYGENASES (FMOS): LONGEVITY-PROMOTING ENZYMES OR ATHEROSCLEROSIS RISK FACTOR?
por: Rossner, Ryan J, et al.
Publicado: (2019)

Deciphering the evolution of flavin-dependent monooxygenase stereoselectivity using ancestral sequence reconstruction
por: Chiang, Chang-Hwa, et al.
Publicado: (2023)

Structural and Biochemical Characterization of the Flavin-Dependent Siderophore-Interacting Protein from Acinetobacter baumannii
por: Valentino, Hannah, et al.
Publicado: (2021)

A Cold-Active Flavin-Dependent Monooxygenase from Janthinobacterium svalbardensis Unlocks Applications of Baeyer–Villiger Monooxygenases at Low Temperature
por: Chánique, Andrea M., et al.
Publicado: (2023)

Effect of Human Flavin-Containing Monooxygenase 3 Polymorphism on the Metabolism of Aurora Kinase Inhibitors
por: Catucci, Gianluca, et al.
Publicado: (2013)

Correction: Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
Publicado: (2017)

Escherichia coli Fails to Efficiently Maintain the Activity of an Important Flavin Monooxygenase in Recombinant Overexpression
por: Milker, Sofia, et al.
Publicado: (2017)

A flavin-dependent monooxygenase catalyzes the initial step in cyanogenic glycoside synthesis in ferns
por: Thodberg, Sara, et al.
Publicado: (2020)

Increased Thermostability of an Engineered Flavin-Containing Monooxygenase to Remediate Trimethylamine in Fish Protein Hydrolysates
por: Goris, Marianne, et al.
Publicado: (2023)

Flavin-Dependent Monooxygenases as a Detoxification Mechanism in Insects: New Insights from the Arctiids (Lepidoptera)
por: Sehlmeyer, Sven, et al.
Publicado: (2010)

Metabolism and Pharmacokinetics of the Anti-Tuberculosis Drug Ethionamide in a Flavin-Containing Monooxygenase Null Mouse
por: Palmer, Amy L., et al.
Publicado: (2012)

Structure-Based Redesign of a Self-Sufficient Flavin-Containing Monooxygenase towards Indigo Production
por: Lončar, Nikola, et al.
Publicado: (2019)

Structural and kinetic insights into flavin-containing monooxygenase and calponin-homology domains in human MICAL3
por: Kim, Junsoo, et al.
Publicado: (2020)

Metabolic Activation of Flavin Monooxygenase-mediated Trimethylamine-N-Oxide Formation in Experimental Kidney Disease
por: Prokopienko, Alexander J., et al.
Publicado: (2019)

A dedicated flavin-dependent monooxygenase catalyzes the hydroxylation of demethoxyubiquinone into ubiquinone (coenzyme Q) in Arabidopsis
por: Latimer, Scott, et al.
Publicado: (2021)

Genomic Survey of Flavin Monooxygenases in Wild and Cultivated Rice Provides Insight into Evolution and Functional Diversities
por: Gaba, Yashika, et al.
Publicado: (2023)

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing
por: Gonzalez Malagon, Sandra G., et al.
Publicado: (2015)

Systematic Theoretical Study on the pH-Dependent Absorption and Fluorescence Spectra of Flavins
por: Wang, Jinyu, et al.
Publicado: (2023)

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria
por: Scott, Flora, et al.
Publicado: (2017)

Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians
por: Dolan, Ciara, et al.
Publicado: (2005)

Independent Recruitment of a Flavin-Dependent Monooxygenase for Safe Accumulation of Sequestered Pyrrolizidine Alkaloids in Grasshoppers and Moths
por: Wang, Linzhu, et al.
Publicado: (2012)

Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry
por: Romero, Elvira, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_kngpe275hsf0jtqg8saekuu0v4