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Development of ProPhenol Ligands for the Diastereo- and Enantioselective Synthesis of β-Hydroxy-α-amino Esters

[Image: see text] A zinc–ProPhenol-catalyzed direct asymmetric aldol reaction between glycine Schiff bases and aldehydes is reported. The design and synthesis of new ProPhenol ligands bearing 2,5-trans-disubstituted pyrrolidines was essential for the success of this process. The transformation opera...

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Detalles Bibliográficos
Autores principales:	Trost, Barry M., Miege, Frédéric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985890/ https://www.ncbi.nlm.nih.gov/pubmed/24502188 http://dx.doi.org/10.1021/ja4129394

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