The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure

[Image: see text] It is generally accepted that DNA predominantly exists in duplex form in cells. However, under torsional stress imposed by active transcription, DNA can assume nonduplex structures. The BCL2 promoter region forms two different secondary DNA structures on opposite strands called the...

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Autores principales: Kendrick, Samantha, Kang, Hyun-Jin, Alam, Mohammad P., Madathil, Manikandadas M., Agrawal, Prashansa, Gokhale, Vijay, Yang, Danzhou, Hecht, Sidney M., Hurley, Laurence H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985915/
https://www.ncbi.nlm.nih.gov/pubmed/24559410
http://dx.doi.org/10.1021/ja410934b

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