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Ligand-Controlled Asymmetric Arylation of Aliphatic α-Amino Anion Equivalents

[Image: see text] A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of α-branched benzylamines.

Detalles Bibliográficos
Autores principales: Zhu, Ye, Buchwald, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985922/
https://www.ncbi.nlm.nih.gov/pubmed/24621247
http://dx.doi.org/10.1021/ja501560x
Descripción
Sumario:[Image: see text] A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of α-branched benzylamines.