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Enhancing the Specificity of Recombinase-Mediated Genome Engineering through Dimer Interface Redesign
[Image: see text] Despite recent advances in genome engineering made possible by the emergence of site-specific endonucleases, there remains a need for tools capable of specifically delivering genetic payloads into the human genome. Hybrid recombinases based on activated catalytic domains derived fr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985937/ https://www.ncbi.nlm.nih.gov/pubmed/24611715 http://dx.doi.org/10.1021/ja4130059 |